| Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan. | |
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MedLine Citation:
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PMID: 10463978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hepatocellular carcinoma (HCC) is the most common malignancy in Taiwan. Some patients may manifest paraneoplastic syndromes during the clinical course of the disease. In this study, the authors evaluated the clinical significance of these paraneoplastic syndromes, compared the prevalence of these syndromes between cases of hepatitis B virus (HBV)-related and hepatitis C virus (HCV)-related HCC, and estimated significant predictors associated with the syndromes. METHODS: Clinical data on 1197 HCC patients, including age, gender, Child-Pugh score, survival time, laboratory data (including liver biochemistry, hepatitis markers, and serum alpha-fetoprotein [AFP]), and tumor features (including tumor size, portal vein thrombosis, and histologic pictures), were retrospectively reviewed. RESULTS: A total of 232 of 1197 patients (19.4%) had paraneoplastic syndromes. HCC patients with paraneoplastic syndromes had significantly higher serum AFP; higher rates of initial main portal vein thrombosis, metastasis, and bilobal tumor involvement; larger tumor volume; and shorter survival than those without these syndromes. Patients with HBV-related HCC had a significantly higher prevalence of paraneoplastic syndromes than patients with HCV-related HCC (20.1% vs. 11.2%, P = 0.005). In a stepwise multivariate logistic regression analysis, AFP >50,000 ng/mL and tumor volume >30% were significant predictive variables associated with the presence of paraneoplastic syndromes in HCC patients. CONCLUSIONS: HCC patients with paraneoplastic syndromes usually had higher levels of serum AFP and larger tumor volumes than those without. Patients with HBV-related HCC had a significantly higher prevalence of paraneoplastic syndromes than those with HCV-related HCC. |
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Authors:
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J C Luo; S J Hwang; J C Wu; C P Li; L T Hsiao; C R Lai; J H Chiang; W Y Lui; F Y Chang; S D Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 86 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-14 Completed Date: 1999-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 799-804 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 1999 American Cancer Society. |
Affiliation:
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Division of Gastroenterology, Veterans General Hospital-Taipei and National Yang-Ming University School of Medicine, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers Carcinoma, Hepatocellular / epidemiology*, metabolism, virology Female Hepatitis B / complications, epidemiology Hepatitis C / complications, epidemiology Humans Liver Neoplasms / epidemiology*, metabolism, virology Logistic Models Male Middle Aged Paraneoplastic Syndromes / epidemiology*, metabolism, virology Prevalence Taiwan / epidemiology alpha-Fetoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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