Document Detail


Paraneoplastic syndromes: detection of malignant tumors using [(18)F]FDG-PET.
MedLine Citation:
PMID:  12865868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Paraneoplastic syndromes (PS) comprise a variety of clinical symptoms and diseases associated with underlying malignancy. Differentiation towards benign autoimmune diseases is necessary due to different therapeutic options. This diagnostic challenge includes cost- and time-consuming methods and is not successful in many cases. The aim of this study was the evaluation of [(18)F]fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET) for detecting or ruling out malignancy in these patients. METHODS: In this retrospective work-up a total of 30 patients with suspected PS (m:f = 17:13, mean age 55, range 22-76 years) were examined with [(18)F]FDG-PET between 1996 and 2001. Diagnoses were erythrodermia, cerebellar degeneration, dermatomyositis, polyneuropathia and others. PET scans were compared to histopathological (n=14), radiological and follow up data (mean follow up 3.6 years, range 1-6 years). RESULTS: In 7 out of 30 patients (23%) an underlying malignancy was detected. Six out of 7 malignant neoplasms showed a distinctly increased glucose consumption. One benign neoplasm caused increased tracer uptake, another PET positive patient refused biopsy and showed no growth of a malignant tumour during clinical follow up of 28 months. The remaining 21 patients without suspicious glucose consumption did not demonstrate a malignancy in other diagnostic modalities or during subsequent clinical follow-up. CONCLUSION: [(18)F]FDG-PET seems to be a useful tool in the diagnostic work-up of patients with suspected paraneoplastic syndrome.
Authors:
U Berner; C Menzel; D Rinne; S Kriener; N Hamscho; N Döbert; M Diehl; R Kaufmann; F Grünwald
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Validation Studies    
Journal Detail:
Title:  The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)     Volume:  47     ISSN:  1125-0135     ISO Abbreviation:  Q J Nucl Med     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2004-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9512274     Medline TA:  Q J Nucl Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Hospital of the Johann Wolfgang Goethe-University, Frankfurt, Germany. u.berner@em.uni-frankfurt.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Male
Middle Aged
Neoplasms / classification,  radionuclide imaging
Paraneoplastic Syndromes / classification*,  pathology,  radiography,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Tomography, Emission-Computed / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

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