| Paraneoplastic syndromes: an approach to diagnosis and treatment. | |
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MedLine Citation:
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PMID: 20810794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hematologic systems. The most commonly associated malignancies include small cell lung cancer, breast cancer, gynecologic tumors, and hematologic malignancies. In some instances, the timely diagnosis of these conditions may lead to detection of an otherwise clinically occult tumor at an early and highly treatable stage. Because paraneoplastic syndromes often cause considerable morbidity, effective treatment can improve patient quality of life, enhance the delivery of cancer therapy, and prolong survival. Treatments include addressing the underlying malignancy, immunosuppression (for neurologic, dermatologic, and rheumatologic paraneoplastic syndromes), and correction of electrolyte and hormonal derangements (for endocrine paraneoplastic syndromes). This review focuses on the diagnosis and treatment of paraneoplastic syndromes, with emphasis on those most frequently encountered clinically. Initial literature searches for this review were conducted using PubMed and the keyword paraneoplastic in conjunction with keywords such as malignancy, SIADH, and limbic encephalitis, depending on the particular topic. Date limitations typically were not used, but preference was given to recent articles when possible. |
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Authors:
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Lorraine C Pelosof; David E Gerber |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 85 ISSN: 1942-5546 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-09-27 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: United States |
Other Details:
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Languages: eng Pagination: 838-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8852, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cushing Syndrome
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diagnosis,
therapy Humans Hypercalcemia / diagnosis, therapy Hypoglycemia / diagnosis, etiology, therapy Inappropriate ADH Syndrome / diagnosis, therapy Paraneoplastic Polyneuropathy / diagnosis, therapy Paraneoplastic Syndromes / blood, diagnosis*, etiology, therapy Parathyroid Hormone-Related Protein / secretion |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR024983-03/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone-Related Protein |
| Comments/Corrections | |
Erratum In:
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Mayo Clin Proc. 2011 Apr;86(4):364 Note: Dosage error in article text |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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