| Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. | |
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MedLine Citation:
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PMID: 22159058 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the features of paraneoplastic syndrome of inappropriate antidiuretic hormone with those of limbic encephalitis. DESIGN: Case study. SETTING: Academic medical center. Patient A 46-year-old woman with progressive memory impairment, hyponatremia, and seizures. INTERVENTIONS: Magnetic resonance imaging of the brain, fluoro-2-deoxyglucose positron emission tomography of the body, and immunohistochemical analysis of a resected tumor. RESULTS: Though the patient presented with clinical features of classic limbic encephalitis, magnetic resonance imaging, electroencephalogram, and cerebrospinal fluid analysis findings were unremarkable. Her chronic hyponatremia was ultimately found to be due to ectopic secretion of antidiuretic hormone by a neuroendocrine tumor with Merkel cell carcinoma phenotype. CONCLUSIONS: Patients presenting with memory impairment, seizures, and hyponatremia should undergo a thorough workup for occult malignancy. In addition to considering classic immune-mediated paraneoplastic limbic encephalitis, the ectopic secretion of antidiuretic hormone should be included in the differential diagnosis. |
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Authors:
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Nicholas A Blondin; Alexander O Vortmeyer; Noam Y Harel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 68 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1591-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Yale University School of Medicine, PO Box 208018, 15 York St, LCI-9, New Haven, CT 06520-8018. nicholas.blondin@yale.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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