| Paraneoplastic rheumatic syndromes. | |
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MedLine Citation:
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PMID: 10985984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. Among these, hypertrophic osteoarthropathy, carcinoma polyarthritis, dermatomyositis/polymyositis, and paraneoplastic vasculitis are the most frequently recognized. Other less known associations are based upon a smaller number of reported patients, and include fasciitis, panniculitis, erythema nodosum, Raynaud's syndrome, digital gangrene, erythromelalgia and lupus-like syndromes. Musculoskeletal manifestations of malignancy may coincide, follow or antedate the diagnosis of cancer, or herald its recurrence. The clinical course generally parallels that of the primary tumour, and treatment of the underlying malignancy often results in regression of the rheumatic disorder. Awareness that cancer can cause certain non-metastatic symptoms is important for early diagnosis and treatment of an occult neoplasm. Rheumatic manifestations suggesting a hidden cancer include: rapid onset of an unusual inflammatory arthritis clubbing or diffuse bone pains in a patient 50 years of age or older, chronic unexplained vasculitis, refractory fasciitis, Raynaud's syndrome unresponsive to vasodilator therapy, rapidly progressive digital gangrene or Lambert-Eaton myasthenic syndrome. Management consists of control of the underlying cancer and symptomatic treatment of the rheumatic syndrome with non-steroidal anti-inflammatory drugs or corticosteroids. |
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Authors:
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A G Fam |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Baillière's best practice & research. Clinical rheumatology Volume: 14 ISSN: - ISO Abbreviation: Baillieres Best Pract Res Clin Rheumatol Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-30 Completed Date: 2000-11-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100883496 Medline TA: Baillieres Best Pract Res Clin Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 515-33 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Muscular Diseases / classification Paraneoplastic Syndromes / classification* Rheumatic Diseases / classification* Skin Diseases / classification Vascular Diseases / classification |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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