Document Detail


Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma.
MedLine Citation:
PMID:  18575019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory neuroepithelium. ENB has no distinctive clinical picture, but often presents as chronic unilateral nasal obstruction or epistaxis. It has a long natural history; the 5-year survival rates have been estimated at 82%. A number of paraneoplastic syndromes have been described in the setting of ENB. Humoral hypercalcemia of malignancy (HHM) has never been described with ENB before. We describe a case of Kadish Stage C ENB with recurrent Hypercalcemia. The hypercalcemia became refractory to therapy and was the cause of death.
Authors:
Subhash Sharma; Wael Lasheen; Declan Walsh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  46     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-5     Citation Subset:  IM    
Affiliation:
Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Esthesioneuroblastoma, Olfactory / secondary*
Fatal Outcome
Humans
Hypercalcemia / etiology*
Male
Middle Aged
Nasal Cavity*
Nose Neoplasms / pathology*
Paraneoplastic Syndromes / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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