Document Detail


Paraneoplastic pemphigus: a refractory autoimmune mucocutaneous disease.
MedLine Citation:
PMID:  12196890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: We report on a 42-year-old man with Stage IIA non-Hodgkin's lymphoma who developed a severe mucocutaneous blistering eruption. His diagnosis, paraneoplastic pemphigus, was based on clinical, histological, and immunofluorescence findings and confirmed by immunoprecipitation. Despite maximal therapy with plasmapheresis, corticosteroids, and mycophenolate mofetil and the subsequent addition of cyclophosphamide and cyclosporine, the condition was fatal.
CONCLUSION: This case illustrates the refractory nature of this disease and the inadequacy of existing therapies.
Authors:
Patricia P L Ng; Adrienne Rencic; H Carlos Nousari
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2002-08-29
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  6     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-06-02     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-7     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Antibiotics, Antineoplastic / therapeutic use
Cyclophosphamide / therapeutic use
Cyclosporine / therapeutic use
Fatal Outcome
Humans
Immunosuppressive Agents / therapeutic use
Lymphoma, Non-Hodgkin / etiology*
Male
Mycophenolic Acid / therapeutic use
Paraneoplastic Syndromes / drug therapy,  etiology*,  pathology
Pemphigus / complications*
Plasmapheresis
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antibiotics, Antineoplastic; 0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 50-18-0/Cyclophosphamide; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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