Document Detail


Paraneoplastic neurological syndromes in patients with carcinoid.
MedLine Citation:
PMID:  19049559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Paraneoplastic neurological syndromes (PNS) are mainly associated with small-cell lung cancer, gynaecological tumours and lymphomas. Few studies report the association of neurological syndromes with a carcinoid, the majority being a serotonin-related myopathy. We report four patients with a PNS associated with carcinoid. PATIENTS AND RESULTS: The clinical syndromes were sensory neuropathy, limbic encephalitis, myelopathy and brain stem encephalitis. Two patients had antineuronal autoantibodies (one anti-Hu, one anti-Yo), one patient had antinuclear antibodies, and one patient had no autoantibodies. For two of the carcinoids, expression of HuD in the tumour could be demonstrated. CONCLUSION: This study demonstrates that carcinoids can also be associated with classical antineuronal antibody-associated PNS.
Authors:
M Tschernatsch; C Dierkes; T Gerriets; J Hosch; E Stolz; M Kaps; I Krasenbrink; D Claus; F Blaes
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  15     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1390-4     Citation Subset:  IM    
Affiliation:
Department of Neurology, Justus-Liebig- University, Am Steg 14, 35385 Giessen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Autoantibodies / immunology
Biological Markers / analysis,  metabolism
Carcinoid Tumor / complications*,  pathology,  physiopathology
Encephalitis / etiology,  pathology,  physiopathology
Female
Hu Paraneoplastic Encephalomyelitis Antigens / immunology
Humans
Limbic Encephalitis / pathology,  physiopathology
Male
Middle Aged
Nerve Tissue Proteins / immunology
Paraneoplastic Polyneuropathy / pathology,  physiopathology
Paraneoplastic Syndromes / etiology*,  pathology,  physiopathology
Spinal Cord Diseases / etiology,  pathology,  physiopathology
Young Adult
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/CDR2 protein, human; 0/Hu Paraneoplastic Encephalomyelitis Antigens; 0/Nerve Tissue Proteins

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