Document Detail

Paraneoplastic nervous system syndromes.
MedLine Citation:
PMID:  8794147     Owner:  NLM     Status:  MEDLINE    
Recent progress in the understanding of the paraneoplastic neurologic syndromes has included further deliniation of the clinical syndromes and their treatment, attempts at standardization of the diagnostic nomenclature, investigations of pathogenetic mechanisms, and molecular characterization of the paraneoplastic antigens with implications as to their biologic relevance. Despite more than 30 years of investigation, the pathogenesis of these presumably autoimmune conditions remains unclear. Furthermore, no effective therapy has been identified for these conditions, with the possible exception of the opsoclonus-myoclonus ataxia and Lambert-Eaton myasthenic syndromes. Future investigations must focus on the disrupted genetic regulatory events involved in generation and propagation of the autoimmune response, antigen presentation and processing; target cell destruction, and consideration of alternative pathologic causes. Effective management strategies are most likely to develop from a better understanding of the disease pathogenesis, the development of animal model systems, and a creative look beyond the usual therapies employed in autoimmune conditions.
K A Jaeckle
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in oncology     Volume:  8     ISSN:  1040-8746     ISO Abbreviation:  Curr Opin Oncol     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-13     Completed Date:  1996-12-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007265     Medline TA:  Curr Opin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-8     Citation Subset:  IM    
Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Antibody Specificity
Autoantibodies / immunology
Autoantigens / genetics,  immunology
Autoimmune Diseases / classification,  diagnosis,  etiology*,  immunology,  therapy
Nervous System Diseases / diagnosis,  etiology*,  immunology,  therapy
Paraneoplastic Syndromes* / classification,  diagnosis,  immunology,  therapy
Terminology as Topic
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens

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