| Paraneoplastic myelopathy. | |
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MedLine Citation:
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PMID: 23186906 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Paraneoplastic causes are a rare but important diagnostic consideration when evaluating myelopathy because neurologic symptoms may herald a diagnosis of cancer. Spinal cord MRI findings of longitudinally extensive, symmetric, tract-specific T2-signal changes occasionally with gadolinium enhancement are characteristic. Detection of neural-specific autoantibodies assists in confirming the diagnosis and guides the cancer search. Initial management involves detection and treatment of the underlying cancer. Combinations of immunotherapies are typically recommended but evidence-based therapeutic guidelines are lacking and morbidity remains high. Autoimmune myelopathies may also occur in association with neural-specific autoantibodies without an underlying cancer and in association with systemic autoimmune disorders. |
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Authors:
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Eoin P Flanagan; B Mark Keegan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurologic clinics Volume: 31 ISSN: 1557-9875 ISO Abbreviation: Neurol Clin Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2012-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8219232 Medline TA: Neurol Clin Country: United States |
Other Details:
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Languages: eng Pagination: 307-18 Citation Subset: IM |
Copyright Information:
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Copyright © 2013 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, Mayo Clinic, 200 First Street South West, Rochester, MN 55905, USA. Electronic address: flanagan.eoin@mayo.edu. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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