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Paraneoplastic myelopathy.
MedLine Citation:
PMID:  23186906     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Paraneoplastic causes are a rare but important diagnostic consideration when evaluating myelopathy because neurologic symptoms may herald a diagnosis of cancer. Spinal cord MRI findings of longitudinally extensive, symmetric, tract-specific T2-signal changes occasionally with gadolinium enhancement are characteristic. Detection of neural-specific autoantibodies assists in confirming the diagnosis and guides the cancer search. Initial management involves detection and treatment of the underlying cancer. Combinations of immunotherapies are typically recommended but evidence-based therapeutic guidelines are lacking and morbidity remains high. Autoimmune myelopathies may also occur in association with neural-specific autoantibodies without an underlying cancer and in association with systemic autoimmune disorders.
Authors:
Eoin P Flanagan; B Mark Keegan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologic clinics     Volume:  31     ISSN:  1557-9875     ISO Abbreviation:  Neurol Clin     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-18     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurology, Mayo Clinic, 200 First Street South West, Rochester, MN 55905, USA. Electronic address: flanagan.eoin@mayo.edu.
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