Document Detail

Paraneoplastic limbic encephalitis in two teenage girls.
MedLine Citation:
PMID:  9706628     Owner:  NLM     Status:  MEDLINE    
Paraneoplastic neurological disorders represent remote effects of cancer without invasion of tumor cells into the nervous system. Limbic encephalitis is a distinct entity mostly associated with small-cell carcinoma of the lung. We present the cases of two teenage girls who were admitted with clinical symptoms typical for limbic encephalitis. In the course of the disease, they exhibited characteristic evolutionary changes of brain MRI abnormalities. Onset of neurological symptoms and type of underlying neoplasia were different in both patients. In one girl the initial workup led to the diagnosis of nodular sclerosing Hodgkin disease which so far had not caused any symptoms besides the described neurological abnormalities. A diagnostic brain biopsy showed inflammatory changes and excluded invasion of malignant cells into the central nervous system. The other patient had been diagnosed with a small cell carcinoma of the ovary several months before neurological and brain MRI abnormalities were observed. This is the first report in which clinical picture, evolution of MRI abnormalities, and--in one case--characteristic neuropathological changes are suggestive of paraneoplastic limbic encephalitis in two adolescent girls.
T Rosenbaum; J Gärtner; D Körholz; G Janssen; D Schneider; V Engelbrecht; U Göbel; H G Lenard
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neuropediatrics     Volume:  29     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-12     Completed Date:  1998-11-12     Revised Date:  2008-01-16    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Department of Neuropediatrics, Heinrich-Heine-Universität Düsseldorf, Germany.
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MeSH Terms
Brain / pathology,  physiopathology
Carcinoma, Small Cell / complications
Disease Progression
Encephalitis / etiology*,  pathology,  physiopathology
Hodgkin Disease / complications
Limbic System*
Lymphatic Metastasis
Magnetic Resonance Imaging
Ovarian Neoplasms / complications
Paraneoplastic Syndromes / etiology*,  physiopathology
Persistent Vegetative State / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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