Document Detail


Paraneoplastic immunobullous disease with an epidermolysis bullosa acquisita phenotype: two cases demonstrating remission with treatment of gynaecological malignancy.
MedLine Citation:
PMID:  15068465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two cases of paraneoplastic immunobullous disease occurring in women with gynaecological malignancies are reported. Both cases demonstrated mechanobullous mucocutaneous blistering as is typically seen in epidermolysis bullosa acquisita. Their immunopathology, however, favoured a dermal-binding mucous membrane pemphigoid (MMP) (or possibly bullous pemphigoid) for patient 1 and laminin-5 MMP for patient 2. Both patients showed resolution of blistering within 1 year of treatment of their malignancies; uterine and ovarian carcinoma, respectively. These cases are of interest because of their paraneoplastic nature; as well as overlapping clinicoimmunopathological features. In addition, patient 2 is, as far as we are aware, the first report of ovarian-carcinoma-associated laminin-5 MMP.
Authors:
Alexander J Chamberlain; Susan M Cooper; Jill Allen; Diane Dean; Kay F Baxter; Mark J D Goodfield; Fenella Wojnarowska
Related Documents :
10448295 - Pilomatrix carcinoma with multiple metastases: report of a case and review of the liter...
10420235 - Adenosquamous carcinoma of the small intestine. report of a case and review of the lite...
6307705 - Studies on nasopharyngeal carcinoma in the sudan--i. epidemiology and aetiology.
18677755 - High-grade neuroendocrine carcinoma presenting as an abscess: diagnosis by fine needle ...
11715845 - Inflammatory pseudotumor of the spleen--a case report.
25177625 - Diclofenac-serratiopeptidase combination induced stevens - johnson syndrome - a rare ca...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  45     ISSN:  0004-8380     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, The Churchill, Oxford Radcliffe Hospitals, Oxford, UK. alex_chamberlain@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma / complications*,  surgery
Carcinoma, Endometrioid / complications,  surgery
Cell Adhesion Molecules / analysis
Epidermolysis Bullosa Acquisita / etiology*,  therapy
Female
Humans
Ovarian Neoplasms / complications*,  surgery
Paraneoplastic Syndromes / etiology*,  therapy
Pemphigoid, Bullous / diagnosis
Phenotype
Remission Induction
Uterine Neoplasms / complications*,  surgery
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/kalinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use of biosynthetic dressings in paraneoplastic pemphigus.
Next Document:  Intralesional 5-fluorouracil in the treatment of keloid scars.