| Paraneoplastic immunobullous disease with an epidermolysis bullosa acquisita phenotype: two cases demonstrating remission with treatment of gynaecological malignancy. | |
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MedLine Citation:
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PMID: 15068465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two cases of paraneoplastic immunobullous disease occurring in women with gynaecological malignancies are reported. Both cases demonstrated mechanobullous mucocutaneous blistering as is typically seen in epidermolysis bullosa acquisita. Their immunopathology, however, favoured a dermal-binding mucous membrane pemphigoid (MMP) (or possibly bullous pemphigoid) for patient 1 and laminin-5 MMP for patient 2. Both patients showed resolution of blistering within 1 year of treatment of their malignancies; uterine and ovarian carcinoma, respectively. These cases are of interest because of their paraneoplastic nature; as well as overlapping clinicoimmunopathological features. In addition, patient 2 is, as far as we are aware, the first report of ovarian-carcinoma-associated laminin-5 MMP. |
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Authors:
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Alexander J Chamberlain; Susan M Cooper; Jill Allen; Diane Dean; Kay F Baxter; Mark J D Goodfield; Fenella Wojnarowska |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Australasian journal of dermatology Volume: 45 ISSN: 0004-8380 ISO Abbreviation: Australas. J. Dermatol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-07 Completed Date: 2004-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0135232 Medline TA: Australas J Dermatol Country: Australia |
Other Details:
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Languages: eng Pagination: 136-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, The Churchill, Oxford Radcliffe Hospitals, Oxford, UK. alex_chamberlain@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma / complications*, surgery Carcinoma, Endometrioid / complications, surgery Cell Adhesion Molecules / analysis Epidermolysis Bullosa Acquisita / etiology*, therapy Female Humans Ovarian Neoplasms / complications*, surgery Paraneoplastic Syndromes / etiology*, therapy Pemphigoid, Bullous / diagnosis Phenotype Remission Induction Uterine Neoplasms / complications*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/kalinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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