Document Detail

Paraneoplastic immunobullous disease with an epidermolysis bullosa acquisita phenotype: two cases demonstrating remission with treatment of gynaecological malignancy.
MedLine Citation:
PMID:  15068465     Owner:  NLM     Status:  MEDLINE    
Two cases of paraneoplastic immunobullous disease occurring in women with gynaecological malignancies are reported. Both cases demonstrated mechanobullous mucocutaneous blistering as is typically seen in epidermolysis bullosa acquisita. Their immunopathology, however, favoured a dermal-binding mucous membrane pemphigoid (MMP) (or possibly bullous pemphigoid) for patient 1 and laminin-5 MMP for patient 2. Both patients showed resolution of blistering within 1 year of treatment of their malignancies; uterine and ovarian carcinoma, respectively. These cases are of interest because of their paraneoplastic nature; as well as overlapping clinicoimmunopathological features. In addition, patient 2 is, as far as we are aware, the first report of ovarian-carcinoma-associated laminin-5 MMP.
Alexander J Chamberlain; Susan M Cooper; Jill Allen; Diane Dean; Kay F Baxter; Mark J D Goodfield; Fenella Wojnarowska
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  45     ISSN:  0004-8380     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  IM    
Department of Dermatology, The Churchill, Oxford Radcliffe Hospitals, Oxford, UK.
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MeSH Terms
Carcinoma / complications*,  surgery
Carcinoma, Endometrioid / complications,  surgery
Cell Adhesion Molecules / analysis
Epidermolysis Bullosa Acquisita / etiology*,  therapy
Ovarian Neoplasms / complications*,  surgery
Paraneoplastic Syndromes / etiology*,  therapy
Pemphigoid, Bullous / diagnosis
Remission Induction
Uterine Neoplasms / complications*,  surgery
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/kalinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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