| Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. | |
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MedLine Citation:
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PMID: 21039714 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 6-year-old intact female Labrador Retriever had diabetes mellitus, which had been difficult to control with insulin. The dog also had a solid ductal mammary carcinoma with very rapid growth, which was temporally related to onset of hypoglycemia. Eight months after initial diagnosis of diabetes, the dog had a hypoglycemic crisis. Insulin administration was stopped and serum glucose concentration returned to normal. Three months after discontinuing insulin, another hypoglycemic crisis occurred. During subsequent months, serum glucose concentrations remained at life-threatening levels (1.64-2.12 mmol/L, reference interval 4.44-6.66 mmol/L) simultaneously with an increase in the size of the mammary tumor, which reached a diameter of about 16 cm. At the time of surgery for removal of the tumor serum glucose concentration was 2.20 mmol/L and was then monitored every 3 hours after excision of the tumor. The glucose concentration continued to rise and reached 9.99 mmol/L 12 hours after the removal of the mammary tumor. Immunohistochemical staining demonstrated expression of insulin growth factor-2 by tumor cells, which apparently had caused the hypoglycemia during tumor growth even in a diabetic dog. Hyperglycemia associated with diabetes was pronounced after excision of the tumor and had been masked by the paraneoplastic effect of the tumor. |
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Authors:
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Gabriele Rossi; Giorgia Errico; Pierpaolo Perez; Giacomo Rossi; Saverio Paltrinieri |
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Publication Detail:
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Type: Journal Article Date: 2010-10-29 |
Journal Detail:
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Title: Veterinary clinical pathology / American Society for Veterinary Clinical Pathology Volume: 39 ISSN: 0275-6382 ISO Abbreviation: Vet Clin Pathol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9880575 Medline TA: Vet Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 480-4 Citation Subset: IM |
Copyright Information:
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©2010 American Society for Veterinary Clinical Pathology. |
Affiliation:
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Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Milan, Italy Veterinary Clinic CVN, Naples, Italy Department of Veterinary Science, Section of Anatomical Pathology, University of Camerino, Matelica (MC), Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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