| Paraneoplastic granulocytosis in metastatic melanoma. | |
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MedLine Citation:
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PMID: 20440226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paraneoplastic syndromes are an uncommon, yet well-described, phenomenon in cancer patients. The syndrome of granulocytosis caused by granulocyte colony-stimulating factor (G-CSF) production by tumors is rare and is difficult to diagnose in patients receiving treatment for metastatic disease. From January 2005 to May 2009, 626 patients were evaluated for treatment of metastatic melanoma. At initial evaluation or during the course of treatment, six patients had an elevated white blood cell count and no evidence of infection. All six had significantly elevated serum G-CSF. The level of serum G-CSF was directly correlated with the absolute neutrophil count. In-vitro assay of melanoma tumor from two patients showed elevated G-CSF in cell culture supernatant. The paraneoplastic syndrome of granulocytosis resulting from ectopic G-CSF production in patients with metastatic melanoma is rare. This diagnosis should be considered when common causes of granulocytosis have been ruled out. |
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Authors:
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Jeremy L Davis; R Taylor Ripley; Timothy L Frankel; Irina Maric; Jay N Lozier; Steven A Rosenberg |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Melanoma research Volume: 20 ISSN: 1473-5636 ISO Abbreviation: Melanoma Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9109623 Medline TA: Melanoma Res Country: England |
Other Details:
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Languages: eng Pagination: 326-9 Citation Subset: IM |
Affiliation:
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Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Granulocyte Colony-Stimulating Factor / blood Granulocytes / pathology* Humans Male Melanoma / blood, complications* Middle Aged Paraneoplastic Syndromes / blood, diagnosis*, etiology Young Adult |
| Chemical | |
Reg. No./Substance:
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143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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