Document Detail

Paraneoplastic granulocytosis in metastatic melanoma.
MedLine Citation:
PMID:  20440226     Owner:  NLM     Status:  MEDLINE    
Paraneoplastic syndromes are an uncommon, yet well-described, phenomenon in cancer patients. The syndrome of granulocytosis caused by granulocyte colony-stimulating factor (G-CSF) production by tumors is rare and is difficult to diagnose in patients receiving treatment for metastatic disease. From January 2005 to May 2009, 626 patients were evaluated for treatment of metastatic melanoma. At initial evaluation or during the course of treatment, six patients had an elevated white blood cell count and no evidence of infection. All six had significantly elevated serum G-CSF. The level of serum G-CSF was directly correlated with the absolute neutrophil count. In-vitro assay of melanoma tumor from two patients showed elevated G-CSF in cell culture supernatant. The paraneoplastic syndrome of granulocytosis resulting from ectopic G-CSF production in patients with metastatic melanoma is rare. This diagnosis should be considered when common causes of granulocytosis have been ruled out.
Jeremy L Davis; R Taylor Ripley; Timothy L Frankel; Irina Maric; Jay N Lozier; Steven A Rosenberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Melanoma research     Volume:  20     ISSN:  1473-5636     ISO Abbreviation:  Melanoma Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-25     Revised Date:  2013-02-11    
Medline Journal Info:
Nlm Unique ID:  9109623     Medline TA:  Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  IM    
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA.
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MeSH Terms
Granulocyte Colony-Stimulating Factor / blood
Granulocytes / pathology*
Melanoma / blood,  complications*
Middle Aged
Paraneoplastic Syndromes / blood,  diagnosis*,  etiology
Young Adult
Grant Support
Z01 SC003811-33/SC/NCI NIH HHS
Reg. No./Substance:
143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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