Document Detail

Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome.
MedLine Citation:
PMID:  15468074     Owner:  NLM     Status:  MEDLINE    
We investigated coexisting autoantibodies in sera of 553 patients with a neurological presentation and one or more paraneoplastic neuronal nuclear or cytoplasmic autoantibodies: antineuronal nuclear autoantibody type 1 (ANNA-1), ANNA-2, ANNA-3; Purkinje cell cytoplasmic autoantibody type 1 (PCA-1), PCA-2; and CRMP-5-immunoglobulin G or amphiphysin-immunoglobulin G. Except for PCA-1, which occurred alone, 31% of sera had more than one of these autoantibodies. In addition, 25% of sera had neuronal calcium channel (P/Q-type or N-type), potassium channel, ganglionic acetylcholine receptor, muscle acetylcholine receptor, or striational antibodies. The autoantibody profiles observed in patients with paraneoplastic disorders imply the targeting of multiple onconeural antigens and predict the patient's neoplasm, but not a specific neurological syndrome.
Sean J Pittock; Thomas J Kryzer; Vanda A Lennon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  56     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-01     Completed Date:  2005-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  715-9     Citation Subset:  IM    
Neurology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Antibodies, Antinuclear / blood,  classification
Autoantibodies / blood*
Blotting, Western / methods
Brain / metabolism
Calcium Channels, P-Type / blood
Cytoplasm / immunology
Fluorescent Antibody Technique / methods
Follow-Up Studies
Gastric Mucosa / metabolism
Immunoglobulin G / blood
Kidney / metabolism
Muscles / metabolism
Neoplasms / blood,  diagnosis*,  immunology*
Nerve Tissue Proteins / blood,  immunology
Paraneoplastic Syndromes, Nervous System / blood,  diagnosis*,  immunology*
Potassium Channels / blood
Predictive Value of Tests
Purkinje Cells / cytology,  immunology
Receptors, Cholinergic / metabolism
Retrospective Studies
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Calcium Channels, P-Type; 0/DPYSL5 protein, human; 0/Immunoglobulin G; 0/Nerve Tissue Proteins; 0/Potassium Channels; 0/Receptors, Cholinergic; 147954-52-7/amphiphysin
Comment In:
Ann Neurol. 2004 Nov;56(5):609-10   [PMID:  15505822 ]

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