Document Detail

Paraneoplastic vitelliform retinopathy: clinicopathologic correlation and review of the literature.
MedLine Citation:
PMID:  22784677     Owner:  NLM     Status:  MEDLINE    
Traditionally, the paraneoplastic retinopathies have been classified into two groups: melanoma-associated retinopathy (MAR) and cancer-associated retinopathy. MAR occurs in individuals with metastatic cutaneous or uveal melanoma and is characterized by nyctalopia, photopsias, and variable vision loss. In most cases, the fundus is essentially normal in appearance. More recently, there have been multiple reports of a MAR-like retinopathy with associated detachments of the retinal pigment epithelium and neurosensory retina. Such a clinical presentation has been termed paraneoplastic vitelliform retinopathy. We describe an 80-year-old man with metastatic cutaneous melanoma who developed paraneoplastic vitelliform retinopathy. For the first time, histopathology from enucleation specimens provides a clinicopathologic disease correlation with focal abnormalities in the inner nuclear and outer plexiform layers.
Mary E Aronow; Grazyna Adamus; Mones Abu-Asab; Yujuan Wang; Chi-Chao Chan; Z Nicholas Zakov; Arun D Singh
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-07-10
Journal Detail:
Title:  Survey of ophthalmology     Volume:  57     ISSN:  1879-3304     ISO Abbreviation:  Surv Ophthalmol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2013-03-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0404551     Medline TA:  Surv Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  558-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
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MeSH Terms
Aged, 80 and over
Autoantibodies / blood
Autoantigens / immunology
Blotting, Western
Carbonic Anhydrase II / immunology
Color Perception Tests
Eye Enucleation
Fluorescein Angiography
Melanoma / immunology,  secondary*
Paraneoplastic Syndromes, Ocular / immunology,  pathology*
Retina / immunology
Retinal Neoplasms / diagnosis,  immunology,  secondary*
Skin Neoplasms / immunology,  pathology*
Tomography, Optical Coherence
Visual Fields
Grant Support
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; EC 4.2.1.-/Carbonic Anhydrase II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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