Document Detail

Paraneoplastic pemphigus in a burn intensive care unit: case report and review of the literature.
MedLine Citation:
PMID:  20683196     Owner:  NLM     Status:  MEDLINE    
Paraneoplastic pemphigus is a rare cause of acute diffuse blistering in the adult patient. It commonly presents with subepidermal blistering, epidermal necrosis, and symptoms of mucosal irritation, such as conjunctivitis and vaginal ulceration. Because of its rarity, it is frequently misdiagnosed as Stevens-Johnson syndrome or toxic epidermal necrolysis. In this study, the authors will describe clinical and histologic manifestations of paraneoplastic pemphigus. This case report describes a 45-year-old woman with paraneoplastic pemphigus who was admitted and treated in a burn intensive care unit. Although initially diagnosed with Stevens-Johnson syndrome, the patient had progression of desquamation when potentially offending medications were discontinued. Diffuse adenopathy was noted on examination, and biopsy confirmed a low-grade lymphoma. Paraneoplastic pemphigus is a rare but important cause of acute diffuse blistering in adults. This disorder should be considered in the differential diagnosis of patients with diffuse blistering.
Awori J Hayanga; Timothy M Lee; Christopher J Pannucci; Brian S Knipp; Stephen H Olsen; Stewart C Wang; Lena M Napolitano
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of burn care & research : official publication of the American Burn Association     Volume:  31     ISSN:  1559-0488     ISO Abbreviation:  J Burn Care Res     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-09     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262774     Medline TA:  J Burn Care Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  826-9     Citation Subset:  IM    
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
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MeSH Terms
Antibodies, Monoclonal, Murine-Derived / therapeutic use
Antineoplastic Agents / therapeutic use
Burns / complications*
Diagnosis, Differential
Intensive Care Units
Middle Aged
Paraneoplastic Syndromes / diagnosis*,  drug therapy,  etiology
Pemphigus / diagnosis*,  drug therapy,  etiology
Stevens-Johnson Syndrome / diagnosis
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal, Murine-Derived; 0/Antineoplastic Agents; 0/rituximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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