| Paraneoplastic pemphigus in a burn intensive care unit: case report and review of the literature. | |
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MedLine Citation:
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PMID: 20683196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paraneoplastic pemphigus is a rare cause of acute diffuse blistering in the adult patient. It commonly presents with subepidermal blistering, epidermal necrosis, and symptoms of mucosal irritation, such as conjunctivitis and vaginal ulceration. Because of its rarity, it is frequently misdiagnosed as Stevens-Johnson syndrome or toxic epidermal necrolysis. In this study, the authors will describe clinical and histologic manifestations of paraneoplastic pemphigus. This case report describes a 45-year-old woman with paraneoplastic pemphigus who was admitted and treated in a burn intensive care unit. Although initially diagnosed with Stevens-Johnson syndrome, the patient had progression of desquamation when potentially offending medications were discontinued. Diffuse adenopathy was noted on examination, and biopsy confirmed a low-grade lymphoma. Paraneoplastic pemphigus is a rare but important cause of acute diffuse blistering in adults. This disorder should be considered in the differential diagnosis of patients with diffuse blistering. |
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Authors:
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Awori J Hayanga; Timothy M Lee; Christopher J Pannucci; Brian S Knipp; Stephen H Olsen; Stewart C Wang; Lena M Napolitano |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of burn care & research : official publication of the American Burn Association Volume: 31 ISSN: 1559-0488 ISO Abbreviation: J Burn Care Res Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262774 Medline TA: J Burn Care Res Country: United States |
Other Details:
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Languages: eng Pagination: 826-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal, Murine-Derived
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therapeutic use Antineoplastic Agents / therapeutic use Biopsy Burns / complications* Diagnosis, Differential Female Humans Intensive Care Units Middle Aged Paraneoplastic Syndromes / diagnosis*, drug therapy, etiology Pemphigus / diagnosis*, drug therapy, etiology Stevens-Johnson Syndrome / diagnosis |
| Grant Support | |
ID/Acronym/Agency:
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T32 GM-08616/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal, Murine-Derived; 0/Antineoplastic Agents; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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