| Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population. | |
| | |
MedLine Citation:
|
PMID: 20629555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The thyroid hormone milieu is of crucial importance for the developing fetus. Pregnancy induces physiological changes in thyroid homeostasis that are influenced by the iodine status. However, longitudinal studies addressing thyroid function during pregnancy and after delivery are still lacking in mild-to-moderate iodine-deficient populations. Here we characterize the serum parameters of thyroid function throughout pregnancy, and until 1 year after delivery, in a population of pregnant women whom we have previously reported to be iodine deficient (median urinary iodine levels below 75 microg/L). METHODS: One hundred eighteen pregnant women were studied. Clinical data were recorded and serum was collected. Serum total and free thyroxine (T(4)) and triiodothyronine (T(3)), thyroid-stimulating hormone, thyroxine-binding globulin, and thyroglobulin were measured. RESULTS: Mean total T(4) ranged from 159 at the start of gestation to 127 nmol/L at 1 year after delivery, free T(4) from 14.2 to 17.8 pmol/L, total T(3) from 2.4 to 2.1 nmol/L, free T(3) from 6.7 pmol/L to 6.4 pmol/L, thyroid-stimulating hormone from 1.2 to 1.4 mIU/L, T(4)-binding globulin from 62.0 to 26.9 mg/L, and thyroglobulin from 11 to 10 microg/L. CONCLUSION: The pregnant women in this study had an absence of the usual free T(4) spike and a smaller than expected increment in total T(4), described during pregnancy in iodine-sufficient populations. A greater number of women had subclinical hypothyroidism compared with iodine-sufficient populations. This hormonal profile, most likely due to iodine insufficiency, may result in inadequate thyroid hormone supply to the developing fetus. We conclude that care should be taken when reviewing the results of thyroid hormone tests in iodine-insufficient populations and when no gestation-specific reference values have been established. In addition, we recommend iodine supplementation in our population and populations with similar iodine status, particularly during pregnancy and lactation. |
| | |
Authors:
|
Maria José Costeira; Pedro Oliveira; Susana Ares; Susana Roque; Gabriella Morreale de Escobar; Joana Almeida Palha |
Related Documents
:
|
21943035 - Accidental natalizumab administration to the third trimester of pregnancy in an adolesc... 10194535 - A negative iodine balance is found in healthy neonates compared with neonates with thyr... 20672905 - Pheochromocytoma and medullary thyroid carcinoma in a pregnant multiple endocrine neopl... 12481755 - Acog practice bulletin. thyroid disease in pregnancy. number 37, august 2002. american ... 3299185 - Detection of fetal movement using doppler ultrasound. 9639345 - Site of catecholamine modulation of feto-maternal electric potential difference in the ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Thyroid : official journal of the American Thyroid Association Volume: 20 ISSN: 1557-9077 ISO Abbreviation: Thyroid Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-09 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
|
Languages: eng Pagination: 995-1001 Citation Subset: IM |
Affiliation:
|
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Humans Iodine / deficiency* Longitudinal Studies Malnutrition / blood Pregnancy Thyroglobulin / blood Thyroid Gland / metabolism* Thyrotropin / blood Thyroxine / blood Thyroxine-Binding Globulin / analysis Triiodothyronine / blood Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Thyroxine-Binding Globulin; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6...
Next Document: Hypothyroidism during antithyroid drug treatment with methimazole is a favorable prognostic indicato...