Document Detail


Paramagnetic capture mode magnetophoretic microseparator for high efficiency blood cell separations.
MedLine Citation:
PMID:  16450037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper presents the characterization of continuous single-stage and three-stage cascade paramagnetic capture (PMC) mode magnetophoretic microseparators for high efficiency separation of red and white blood cells from diluted whole blood based on their native magnetic properties. The separation mechanism for both PMC microseparators is based on a high gradient magnetic separation (HGMS) method. This approach enables separation of blood cells without the use of additives such as magnetic beads. Experimental results for the single-stage PMC microseparator show that 91.1% of red blood cells were continuously separated from the sample at a volumetric flow rate of 5 microl h-1. In addition, the three-stage cascade PMC microseparator continuously separated 93.5% of red blood cells and 97.4% of white blood cells from whole blood at a volumetric flow rate of 5 microl h-1.
Authors:
Ki-Ho Han; A Bruno Frazier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-12-19
Journal Detail:
Title:  Lab on a chip     Volume:  6     ISSN:  1473-0197     ISO Abbreviation:  Lab Chip     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-04-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-73     Citation Subset:  IM    
Affiliation:
School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive, Atlanta, GA 30332, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Cell Separation / methods*
Erythrocytes / cytology*
Leukocyte Count
Magnetics / instrumentation*
Grant Support
ID/Acronym/Agency:
ES10846/ES/NIEHS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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