Document Detail

Paralytic and insecticidal toxins from the funnel web spider, Hololena curta.
MedLine Citation:
PMID:  2048147     Owner:  NLM     Status:  MEDLINE    
One peptide and ten acylpolyamine toxins (curtatoxins) were purified and identified from venom of Hololena curta. The acylpolyamines consist of six different polyamines which are amidated with three different aromatic acids: (3-indolyl)acetic, (4-hydroxy-3-indolyl)acetic and 2.5-dihydroxybenzoic acids. These acylpolyamines instantly paralyze lepidopteran larvae following injection. The most potent insecticidal peptide in H. curta venom contains 38 amino acids and is lethal at 4 micrograms/g when injected into Manduca sexta larvae.
G B Quistad; C C Reuter; W S Skinner; P A Dennis; S Suwanrumpha; E W Fu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  29     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-16     Completed Date:  1991-07-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-36     Citation Subset:  IM    
Sandoz Crop Protection Corporation, Palo Alto, CA 94304-1104.
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MeSH Terms
Amino Acid Sequence
Insecticides / isolation & purification*
Molecular Sequence Data
Moths / drug effects
Neurotoxins / isolation & purification*,  toxicity
Paralysis / chemically induced
Spider Venoms / analysis*
Reg. No./Substance:
0/Insecticides; 0/Neurotoxins; 0/Spider Venoms

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