Document Detail


Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type.
MedLine Citation:
PMID:  18249009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hippocampal surface structure was assessed at twice 2 years apart in 26 nondemented subjects (CDR 0), in 18 subjects with early dementia of Alzheimer type (DAT, CDR 0.5), and in 9 subjects who converted from the nondemented (CDR 0) to the demented (CDR 0.5) state using magnetic resonance (MR) imaging. We used parallel transport in diffeomorphisms under the large deformation diffeomorphic metric mapping framework to translate within-subject deformation of the hippocampal surface as represented in the MR images between the two time points in a global template coordinate system. We then performed hypothesis testing on the longitudinal variation of hippocampal shape in the global template. Both subjects with early DAT and converters showed greater rates of hippocampal deformation across time than nondemented controls within every subfield of the hippocampus. In a random field analysis, inward surface deformation across time occurred in a non-uniform manner across the hippocampal surface in subjects with early DAT relative to the nondemented controls. Also, compared to the controls, the lateral aspect of the left hippocampal tail showed inward surface deformation in the converters. Using surface deformation patterns as features in a linear discriminant analysis, we were able to respectively distinguish converters and patients with early DAT from healthy nondemented controls at classification rates of 0.77 and 0.87, which were obtained in the same training set using the leave-one-out cross validation approach.
Authors:
Anqi Qiu; Laurent Younes; Michael I Miller; John G Csernansky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-12-08
Journal Detail:
Title:  NeuroImage     Volume:  40     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-04-23     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / pathology*,  physiology*
Algorithms
Alzheimer Disease / pathology*
Brain Mapping
Data Interpretation, Statistical
Female
Hippocampus / growth & development,  pathology*
Humans
Image Processing, Computer-Assisted
Longitudinal Studies
Magnetic Resonance Imaging
Male
Normal Distribution
Grant Support
ID/Acronym/Agency:
P01 AG 03991/AG/NIA NIH HHS; P01 AG003991/AG/NIA NIH HHS; P01 AG003991-250013/AG/NIA NIH HHS; P41 RR 15241/RR/NCRR NIH HHS; P41 RR015241/RR/NCRR NIH HHS; P41 RR015241-060004/RR/NCRR NIH HHS; P50 AG 05681/AG/NIA NIH HHS; P50 AG005681/AG/NIA NIH HHS; P50 AG005681-25/AG/NIA NIH HHS; P50 MH 071616/MH/NIMH NIH HHS; P50 MH071616/MH/NIMH NIH HHS; P50 MH071616-050001/MH/NIMH NIH HHS; R01 AG 025824/AG/NIA NIH HHS; R01 AG025824/AG/NIA NIH HHS; R01 AG025824-04/AG/NIA NIH HHS; R01 EB 00975/EB/NIBIB NIH HHS; R01 EB000975/EB/NIBIB NIH HHS; R01 EB000975-05A2/EB/NIBIB NIH HHS; R01 MH 064838/MH/NIMH NIH HHS; R01 MH060883/MH/NIMH NIH HHS; R01 MH060883-09/MH/NIMH NIH HHS; R01 O60883//PHS HHS
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