Document Detail

Parallel observation of four methods for screening women under 25 years of age for genital infection with Chlamydia trachomatis.
MedLine Citation:
PMID:  12593898     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare four methods of screening women for Chlamydia trachomatis in an obstetrics and gynaecology department. STUDY DESIGN: A total of 303 healthy women under 25 years were recruited from antenatal, induced abortion, and family planning clinics. Each underwent parallel testing of endocervical specimens by enzyme immunoassay (EIA) and ligase chain reaction (LCR), vulval swabs by LCR, and urine by LCR. Outcome measures included sensitivity, specificity, acceptability of each method, and the influence of pregnancy. RESULTS: Overall prevalence (95% CI) was 9.9% (6.8-14%). All methods had a high rate of detection (75-100%), not affected by pregnancy. Urine was most acceptable, followed by vulval swabbing. CONCLUSIONS: Opportunistic screening of women under 25 years attending obstetric and gynaecology affiliated clinics found high rates of C. trachomatis infection. Both urine and vulval swab methods were highly sensitive, acceptable, and not affected by pregnancy status. Due to pragmatic issues surrounding the urine method, screening by vulval swabs deserves wider recognition.
Susan Macmillan; Hamish McKenzie; Allan Templeton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  107     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-20     Completed Date:  2003-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK.
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MeSH Terms
Cervix Uteri / microbiology
Chlamydia Infections / diagnosis*,  epidemiology
Chlamydia trachomatis / genetics,  isolation & purification*
DNA, Bacterial / analysis
Immunoenzyme Techniques
Mass Screening / methods*
Nucleic Acid Amplification Techniques
Patient Satisfaction
Sensitivity and Specificity
Specimen Handling
Urine / microbiology
Vagina / microbiology
Vulva / microbiology
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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