| Parallel molecular evolution in an herbivore community. | |
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MedLine Citation:
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PMID: 23019645 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Numerous insects have independently evolved the ability to feed on plants that produce toxic secondary compounds called cardenolides and can sequester these compounds for use in their defense. We surveyed the protein target for cardenolides, the alpha subunit of the sodium pump, Na(+),K(+)-ATPase (ATPα), in 14 species that feed on cardenolide-producing plants and 15 outgroups spanning three insect orders. Despite the large number of potential targets for modulating cardenolide sensitivity, amino acid substitutions associated with host-plant specialization are highly clustered, with many parallel substitutions. Additionally, we document four independent duplications of ATPα with convergent tissue-specific expression patterns. We find that unique substitutions are disproportionately associated with recent duplications relative to parallel substitutions. Together, these findings support the hypothesis that adaptation tends to take evolutionary paths that minimize negative pleiotropy. |
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Authors:
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Ying Zhen; Matthew L Aardema; Edgar M Medina; Molly Schumer; Peter Andolfatto |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 337 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1634-7 Citation Subset: IM |
Affiliation:
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Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/JQ771496; JQ771497; JQ771498; JQ771499; JQ771500; JQ771501; JQ771502; JQ771503; JQ771504; JQ771505; JQ771506; JQ771507; JQ771508; JQ771509; JQ771510; JQ771511; JQ771512; JQ771513; JQ771514; JQ771515; JQ771516; JQ771517; JQ771518; JQ771519; JQ771520; JQ771521; JQ771522; JQ771523; JQ771524; JQ771525; JQ771526; JQ771527 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01-GM083228/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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