Document Detail


Parallel molecular evolution in an herbivore community.
MedLine Citation:
PMID:  23019645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous insects have independently evolved the ability to feed on plants that produce toxic secondary compounds called cardenolides and can sequester these compounds for use in their defense. We surveyed the protein target for cardenolides, the alpha subunit of the sodium pump, Na(+),K(+)-ATPase (ATPα), in 14 species that feed on cardenolide-producing plants and 15 outgroups spanning three insect orders. Despite the large number of potential targets for modulating cardenolide sensitivity, amino acid substitutions associated with host-plant specialization are highly clustered, with many parallel substitutions. Additionally, we document four independent duplications of ATPα with convergent tissue-specific expression patterns. We find that unique substitutions are disproportionately associated with recent duplications relative to parallel substitutions. Together, these findings support the hypothesis that adaptation tends to take evolutionary paths that minimize negative pleiotropy.
Authors:
Ying Zhen; Matthew L Aardema; Edgar M Medina; Molly Schumer; Peter Andolfatto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  337     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2012-10-02     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1634-7     Citation Subset:  IM    
Affiliation:
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/JQ771496;  JQ771497;  JQ771498;  JQ771499;  JQ771500;  JQ771501;  JQ771502;  JQ771503;  JQ771504;  JQ771505;  JQ771506;  JQ771507;  JQ771508;  JQ771509;  JQ771510;  JQ771511;  JQ771512;  JQ771513;  JQ771514;  JQ771515;  JQ771516;  JQ771517;  JQ771518;  JQ771519;  JQ771520;  JQ771521;  JQ771522;  JQ771523;  JQ771524;  JQ771525;  JQ771526;  JQ771527
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / genetics*
Amino Acid Sequence
Amino Acid Substitution
Animals
Apocynaceae / metabolism*,  parasitology
Cardenolides / metabolism*
Evolution, Molecular*
Genetic Pleiotropy
Herbivory / genetics*
Host-Parasite Interactions / genetics*
Insects / enzymology,  genetics*,  physiology
Molecular Sequence Data
Organ Specificity
Sodium-Potassium-Exchanging ATPase / chemistry,  genetics*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 GM083228/GM/NIGMS NIH HHS; R01-GM083228/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cardenolides; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase
Comments/Corrections

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