Document Detail


Parallel mechanisms of epigenetic reprogramming in the germline.
MedLine Citation:
PMID:  22386917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Germ cells possess the extraordinary and unique capacity to give rise to a new organism and create an enduring link between all generations. To acquire this property, primordial germ cells (PGCs) transit through an unprecedented programme of sequential epigenetic events that culminates in an epigenomic basal state that is the foundation of totipotency. This process is underpinned by genome-wide DNA demethylation, which may occur through several overlapping pathways, including conversion to 5-hydroxymethylcytosine. We propose that the epigenetic programme in PGCs operates through multiple parallel mechanisms to ensure robustness at the level of individual cells while also being flexible through functional redundancy to guarantee high fidelity of the process. Gaining a better understanding of the molecular mechanisms that direct epigenetic reprogramming in PGCs will enhance our ability to manipulate epigenetic memory, cell-fate decisions and applications in regenerative medicine.
Authors:
Jamie A Hackett; Jan J Zylicz; M Azim Surani
Related Documents :
1135627 - Neuronal excitability modulation over the sleep cycle: a structural and mathematical mo...
9219697 - In vitro propagation of the prion-like state of yeast sup35 protein.
21356757 - Chicken erythrocyte histone octamer preparation.
14509337 - Modeling of the whole expanded-bed protein adsorption process with yeast cell suspensio...
4598227 - Isolation of polyribosomes from yeast during sporulation and vegetative growth.
23686387 - Fine mechanisms of the interaction of silver nanoparticles with the cells of salmonella...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-03
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  28     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-08     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage
DNA Methylation
Epigenesis, Genetic*
Germ Cells / cytology,  metabolism*
Humans
Nuclear Reprogramming*
Grant Support
ID/Acronym/Agency:
092096//Wellcome Trust; G0800784//Medical Research Council; RG49135//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of patient effective dose from sentinel lymph node lymphoscintigraphy in breast cancer: A...
Next Document:  In vivo targeting and positron emission tomography imaging of tumor vasculature with (66)Ga-labeled...