Document Detail

Parallel mechanisms of epigenetic reprogramming in the germline.
MedLine Citation:
PMID:  22386917     Owner:  NLM     Status:  MEDLINE    
Germ cells possess the extraordinary and unique capacity to give rise to a new organism and create an enduring link between all generations. To acquire this property, primordial germ cells (PGCs) transit through an unprecedented programme of sequential epigenetic events that culminates in an epigenomic basal state that is the foundation of totipotency. This process is underpinned by genome-wide DNA demethylation, which may occur through several overlapping pathways, including conversion to 5-hydroxymethylcytosine. We propose that the epigenetic programme in PGCs operates through multiple parallel mechanisms to ensure robustness at the level of individual cells while also being flexible through functional redundancy to guarantee high fidelity of the process. Gaining a better understanding of the molecular mechanisms that direct epigenetic reprogramming in PGCs will enhance our ability to manipulate epigenetic memory, cell-fate decisions and applications in regenerative medicine.
Jamie A Hackett; Jan J Zylicz; M Azim Surani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-03
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  28     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-08     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Cell Lineage
DNA Methylation
Epigenesis, Genetic*
Germ Cells / cytology,  metabolism*
Nuclear Reprogramming*
Grant Support
092096//Wellcome Trust; G0800784//Medical Research Council; RG49135//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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