| Parallel effects of DOCA on salt appetite, thirst, and blood pressure in sheep. | |
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MedLine Citation:
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PMID: 3368478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salt appetite was quantified in sheep by measuring the relative amounts of high-salt (266 meq/kg) and low-salt (6 meq/kg) pelleted alfalfa that they ate. Given a choice of these two foods, normal sheep ate twice as much low-salt as high-salt pellets. Following DOCA administration the sheep rapidly developed an increased salt appetite, and after 10 days they ate approximately three times as much high-salt as low-salt pellets. Their choice rapidly reverted to control values after the end of the DOCA treatment. The changes in salt appetite were accompanied by changes in thirst and mean arterial pressure. We hypothesize that these effects of DOCA reflect changes that parallel those this mineralocorticoid causes in the hypothalamic regulatory centers for salt appetite, thirst, and blood pressure. |
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Authors:
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M N Hamlin; R C Webb; W D Ling; D F Bohr |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 188 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-06-16 Completed Date: 1988-06-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Michigan, Ann Arbor 48109. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite / drug effects* Blood Pressure / drug effects* Desoxycorticosterone / pharmacology* Potassium / blood Sheep Sodium / blood Sodium Chloride* Thirst / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-18575/HL/NHLBI NIH HHS; HL27020/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-85-7/Desoxycorticosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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