Document Detail

Parallel effects of DOCA on salt appetite, thirst, and blood pressure in sheep.
MedLine Citation:
PMID:  3368478     Owner:  NLM     Status:  MEDLINE    
Salt appetite was quantified in sheep by measuring the relative amounts of high-salt (266 meq/kg) and low-salt (6 meq/kg) pelleted alfalfa that they ate. Given a choice of these two foods, normal sheep ate twice as much low-salt as high-salt pellets. Following DOCA administration the sheep rapidly developed an increased salt appetite, and after 10 days they ate approximately three times as much high-salt as low-salt pellets. Their choice rapidly reverted to control values after the end of the DOCA treatment. The changes in salt appetite were accompanied by changes in thirst and mean arterial pressure. We hypothesize that these effects of DOCA reflect changes that parallel those this mineralocorticoid causes in the hypothalamic regulatory centers for salt appetite, thirst, and blood pressure.
M N Hamlin; R C Webb; W D Ling; D F Bohr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  188     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-16     Completed Date:  1988-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-51     Citation Subset:  IM    
Department of Physiology, University of Michigan, Ann Arbor 48109.
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MeSH Terms
Appetite / drug effects*
Blood Pressure / drug effects*
Desoxycorticosterone / pharmacology*
Potassium / blood
Sodium / blood
Sodium Chloride*
Thirst / drug effects*
Grant Support
Reg. No./Substance:
64-85-7/Desoxycorticosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride

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