Document Detail

Parallel decrease in arterial distensibility and in endothelium-dependent dilatation in young women with a history of pre-eclampsia.
MedLine Citation:
PMID:  19886852     Owner:  NLM     Status:  MEDLINE    
Pre-eclampsia not only complicates 5 to 8% of pregnancies but also increases the risk of maternal cardiovascular disease and mortality later in life. We analyzed three different aspects of arterial function (pulse wave velocity, augmentation index, and flow-mediated dilatation), in 55 nonpregnant, normotensive women (18-33 years old) according to their gestational history: 15 nulliparous, 20 with a previous normotensive, and 20 formerly pre-eclamptic pregnancy. Former pre-eclamptic women showed a significantly higher augmentation index and pulse wave velocity (P < 0.001 and P < 0.05, respectively) and lower flow-mediated dilatation (p = 0.01) compared to control groups. In contrast, sublingual nitroglycerine elicited a comparable vasodilatory response in the three groups. The augmentation index correlated significantly with pulse wave velocity and flow-mediated dilatation (R = 0.28 and R = -0.32, respectively, P < 0.05 for both). No significant correlations were observed between augmentation index or flow-mediated dilatation with age, body mass index (BMI), brachial blood pressure, heart rate, or metabolic parameters (plasma cholesterol, glucose, insulin, or insulin resistance). Birth weight maintained a significantly inverse correlation with the augmentation index (R = -0.51, p < 0.002) but not with flow-mediated dilatation. Our findings revealed a parallel decrease in arterial distensibility and endothelium-dependent dilatation in women with a history of pre-eclampsia compared to nulliparous women and women with a previous normal pregnancy. A high augmentation index was the most consistent alteration associated with a history of pre-eclampsia. The study supports the current view that the generalized arterial dysfunction associated with pre-eclampsia persists subclinically after delivery.
Olga P??ez; Jos?? Alfie; Marta Gorosito; Pablo Puleio; Marcelo de Maria; Noem?? Prieto; Claudio Majul
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  31     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  544-52     Citation Subset:  IM    
Secci??n de Hipertensi??n Arterial, Servicio de Cardiologia, Hospital Santojanni, Buenos Aires, Argentina.
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MeSH Terms
Birth Weight / physiology
Blood Flow Velocity / physiology
Carotid Arteries / physiopathology
Case-Control Studies
Cross-Sectional Studies
Endothelium, Vascular / physiopathology
Femoral Artery / physiopathology
Infant, Newborn
Nitroglycerin / pharmacology
Parity / physiology
Pre-Eclampsia / physiopathology*
Vasodilation / drug effects,  physiology*
Vasodilator Agents / pharmacology
Young Adult
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

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