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Parallel artificial membrane permeability assay (PAMPA) - Is it better than Caco-2 for human passive permeability prediction?
MedLine Citation:
PMID:  21044031     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This review proposes a statistical and qualitative comparison between the main techniques derived from the original PAMPA method and experimental results obtained from Caco-2 and human jejunum. Among them, PAMPA techniques variations developed by some of the most renowned authors on the subject. The comparison is made from 16 common structurally diverse molecules, taking into account mainly membrane lipid composition and incubation conditions. A BCS classification prediction of the studied molecules was also possible to make. Finally, it was possible to raise and prove important previous hypotheses, aside from pointing out the best PAMPA model to predict human data.
Authors:
J M Reis; B Sinkó; C H R Serra
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  10     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1071-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, School of Pharmaceutical Sciences, São Paulo University, 580 Prof. Lineu Prestes Avenue, Bl. 13, 05508-900 São Paulo, SP, Brazil.
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