| Paradoxically high adiponectin and the healthy obese phenotype in obese black and white 16-year-old girls. | |
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MedLine Citation:
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PMID: 20970753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although adiponectin is correlated inversely with obesity, some obese adults without metabolic complications of obesity have paradoxically high adiponectin. Therefore, we assessed adiponectin risk factor relations in 133 obese 16-year-old school girls from a cohort of 448, focusing on paradoxically high adiponectin-risk in obesity and the healthy obese phenotype. Median adiponectin (11.9 mg/L) in nonobese girls (body mass index [BMI] < 24.6 kg/m²) was selected as a cutpoint to identify high adiponectin in obese girls. Of 90 black and 43 white obese girls (BMI ≥ 24.6), 25 black (28%) and 13 white (30%) girls had paradoxically high adiponectin (>11.9). The 38 obese girls with adiponectin >11.9 versus the 95 obese girls with adiponectin ≤11.9 had higher median high-density lipoprotein (HDL) cholesterol (54 vs 46 mg/dL, P = 0.0007) and apolipoprotein A1 (ApoA1) (181 vs 164 mg/dL, P = 0.011) and had lower insulin (14 vs 20 uU/mL, P = 0.0006). In the 133 obese girls, through stepwise regression, the adiponectin category (>11.9, ≤ 11.9 mg/L) was a significant independent positive determinant of HDL cholesterol (partial r² = 8.4%, P = 0.001), ApoA1 (partial r² = 4.1%, P = 0.025), and it was associated inversely with fasting serum insulin (partial r² = 5.4%, P = 0.0074). By stepwise logistic regression in the 133 obese girls, the adiponectin category (high vs low) was a significant inverse explanatory variable for metabolic syndrome (odds ratio 0.20, 95% confidence intervals 0.04-0.95, P = 0.043). We conclude that paradoxically high adiponectin is associated with the healthy obese phenotype in obese adolescent black and white girls. |
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Authors:
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John A Morrison; Charles J Glueck; Stephen Daniels; Ping Wang; Paul Horn; Davis Stroop |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 156 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2010-11-09 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 302-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adolescent African Continental Ancestry Group / ethnology Body Mass Index Cohort Studies European Continental Ancestry Group / ethnology Female Humans Obesity / blood*, ethnology Phenotype Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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HL48941/HL/NHLBI NIH HHS; HL52911/HL/NHLBI NIH HHS; HL55025/HL/NHLBI NIH HHS; HL66430/HL/NHLBI NIH HHS; M01 RR008084-090126/RR/NCRR NIH HHS; U01 HL048941-07/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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