Document Detail

Paradoxical sleep deprivation induces muscle atrophy.
MedLine Citation:
PMID:  22334180     Owner:  NLM     Status:  In-Data-Review    
Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012.
Murilo Dattilo; Hanna Karen Moreira Antunes; Alessandra Medeiros; Marcos Mônico-Neto; Helton de Sá Souza; Kil Sun Lee; Sergio Tufik; Marco Túlio de Mello
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  45     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Professor Francisco de Castro, 93 Vila Clementino, CEP 04020-050, São Paulo, SP, Brazil; Centro de Estudos em Psicobiologia e Exercício (CEPE), São Paulo, Brazil.
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