Document Detail


Paradoxical sleep deprivation activates hypothalamic nuclei that regulate food intake and stress response.
MedLine Citation:
PMID:  19346078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large body of evidence has shown that prolonged paradoxical sleep deprivation (PSD) results in hypothalamic-pituitary-adrenal (HPA) axis activation, and in loss of body weight despite an apparent increase of food intake, reflecting increased energy expenditure. The flowerpot technique for PSD is an efficient paradigm for investigating the relationships among metabolic regulation and stress response. The purpose of the present study was to examine the mechanisms involved in the effects of 96 h of PSD on metabolism regulation, feeding behaviour and stress response by studying corticotrophin-releasing hormone (CRH) and orexin (ORX) immunoreactivity in specific hypothalamic nuclei. Once-daily assessments of body weight, twice-daily measurements of (spillage-corrected) food intake, and once-daily determinations of plasma adrenocorticotropic hormone (ACTH) and corticosterone were made throughout PSD or at corresponding times in control rats (CTL). Immunoreactivity for CRH in the paraventricular nucleus of the hypothalamus and for ORX in the hypothalamic lateral area was evaluated at the end of the experimental period. PSD resulted in increased diurnal, but not nocturnal, food intake, producing no significant changes in global food intake. PSD augmented the immunoreactivity for CRH and plasma ACTH and corticosterone levels, characterizing activation of the HPA axis. PSD also markedly increased the ORX immunoreactivity. The average plasma level of corticosterone correlated negatively with body weight gain throughout PSD. These results indicate that augmented ORX and CRH immunoreactivity in specific hypothalamic nuclei may underlie some of the metabolic changes consistently described in PSD.
Authors:
Milene de Oliveira Lara Galvão; Rita Sinigaglia-Coimbra; Suzi Emiko Kawakami; Sergio Tufik; Deborah Suchecki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-05
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  34     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1176-83     Citation Subset:  IM    
Affiliation:
Department of Psychobiology, Universidade Federal de São Paulo, R. Napoleão de Barros, 925, São Paulo, SP 04024-002, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Body Weight / physiology
Corticosterone / blood
Corticotropin-Releasing Hormone / metabolism
Eating / physiology*
Hypothalamic Area, Lateral / metabolism
Hypothalamus / metabolism*
Intracellular Signaling Peptides and Proteins / metabolism
Male
Neuropeptides / metabolism
Random Allocation
Rats
Rats, Wistar
Sleep Deprivation / metabolism*
Stress, Physiological / physiology*
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins; 50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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