Document Detail

Paradoxical response of sphincter of Oddi to intravenous injection of cholecystokinin or ceruletide. Manometric findings and results of treatment in biliary dyskinesia.
MedLine Citation:
PMID:  3804027     Owner:  NLM     Status:  MEDLINE    
Sixty two patients with a clinical suspicion of biliary dyskinesia were investigated with endoscopic manometry of the sphincter of Oddi before and after intravenous injection of cholecystokinin or ceruletide. In 52 patients injection was followed by decreased pressure in the sphincter of Oddi; 43 of these had normal prestimulatory values (group I), while the values were raised in the other nine patients (group II). A paradoxical response to intravenous injection was observed in 10 women (group III): increased baseline sphincteric pressure occurred in eight and increase in the amplitude of phasic contractions in four patients. The prestimulatory sphincteric pressure was raised in five and normal in the remaining patients. Eight patients were treated with papillotomy (seven) or balloon dilatation of the sphincter (one). They experienced relief of pain during a follow up period of 11-16 months. Intravenous injection of cholecystokinin or ceruletide may disclose a special type of biliary dyskinesia even in patients with normal prestimulatory manometric findings. Hormone injection increases the diagnostic yield of endoscopic manometry in patients suspected of biliary dyskinesia.
P Rolny; A Arlebäck; P Funch-Jensen; A Kruse; J Ravnsbaeck; G Järnerot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  27     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-03-18     Completed Date:  1987-03-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1507-11     Citation Subset:  AIM; IM    
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MeSH Terms
Ampulla of Vater / drug effects*
Biliary Dyskinesia / physiopathology*,  therapy
Caerulein / diagnostic use*
Cholecystokinin / diagnostic use*
Middle Aged
Sphincter of Oddi / drug effects*,  physiopathology
Reg. No./Substance:
17650-98-5/Caerulein; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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