| Paradoxical effects of exogenous proteins on lung function in surfactant-deficient rats. | |
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MedLine Citation:
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PMID: 10923245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leakage of plasma proteins into the alveolar space can inhibit pulmonary surfactant function and worsen respiratory failure in ventilated preterm infants. We tested the effect of intratracheal instillation of fetal calf serum (FCS) and fresh frozen plasma (FFP) on lung function in ventilated rats who were made surfactant-deficient by saline lavage. Post lavage, the rats were treated with air placebo, Survanta, FCS or FFP, air placebo + FCS or FFP 1 hour post lavage, or Survanta + FCS or FFP 1 hour post lavage. After 2 hours of ventilation, pressure volume curves were performed and the lungs relavaged. FCS instillation rapidly improved oxygenation when given immediately post lavage or 1 hour after placebo or Survanta instillation, whereas FFP instillation never improved oxygenation. FCS instillation increased post-treatment lavage phospholipid values, but FFP did not. Both FCS and FFP decreased lung volume, but the negative effect of FFP exceeded that of FCS. Surfactant aggregate sizing of the final lung lavages by dynamic light scattering showed a definite shift towards smaller aggregates after FFP, but not after FCS, instillation. These data suggest that intratracheal instillation of FCS improves oxygenation and preserves the alveolar presence of phospholipids and large surfactant aggregates, whereas FFP decreases oxygenation and surfactant aggregate size in surfactant-deficient lavaged rats. |
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Authors:
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F J Walther; M Gupta; N Mbagwu; J M Hernandez-Juviel; R Bruni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental lung research Volume: 26 ISSN: 0190-2148 ISO Abbreviation: Exp. Lung Res. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-12-28 Completed Date: 2000-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 273-85 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Charles R. Drew University of Medicine and Science, Los Angeles, California, USA. fwalther@ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Blood Proteins / metabolism, pharmacology* Bronchoalveolar Lavage Fluid / chemistry Cattle Disease Models, Animal Fetal Blood Humans Lung Volume Measurements Male Particle Size Phospholipids / metabolism Plasma Proteins / metabolism Pulmonary Surfactants / antagonists & inhibitors, deficiency* Rats Rats, Sprague-Dawley Respiratory Function Tests Scattering, Radiation Surface Tension / drug effects Trachea |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Phospholipids; 0/Proteins; 0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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