Document Detail

Paradoxical effect of neuroleptic drugs on prolactin secretion by rat pituitary cell cultures.
MedLine Citation:
PMID:  10530797     Owner:  NLM     Status:  MEDLINE    
Several antipsychotic drugs reverse the dopamine-induced inhibition of prolactin release by rat pituitary cell cultures. Paradoxically, at high doses and without dopamine, antipsychotic drugs can also inhibit prolactin secretion. The mechanism underlying this phenomenon is unclear. Some evidence suggests that these drugs have an agonistic action. We sought to verify whether clozapine and fluphenazine, at doses higher than those reversing dopamine-induced inhibition of prolactin secretion in vitro, show this paradoxical effect and eventually a partial agonistic action. Both antipsychotics inhibited prolactin secretion, clozapine at doses starting from 10(-6) M and fluphenazine from 10(-7) M. Haloperidol reversed clozapine-induced prolactin inhibition but left fluphenazine-induced inhibition unchanged. These in vitro findings suggest that clozapine has a partial agonistic action on dopaminergic receptors but fluphenazine does not.
L Braghiroli; A Ponzianelli; G Mazzanti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  65     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-05     Completed Date:  1999-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1455-61     Citation Subset:  IM    
Institute of Pharmacology and Pharmacognosy, University of Rome La Sapienza, Italy.
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MeSH Terms
Antipsychotic Agents / pharmacology*
Cell Survival / drug effects
Cells, Cultured
Clozapine / pharmacology
Fluphenazine / pharmacology
Pituitary Gland / cytology,  drug effects*,  secretion
Prolactin / secretion*
Rats, Wistar
Secretory Rate / drug effects
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine; 69-23-8/Fluphenazine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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