Document Detail

Paradoxical drug response and the placebo effect: a discussion of Grunbaum's definitional scheme.
MedLine Citation:
PMID:  12735487     Owner:  NLM     Status:  MEDLINE    
Grunbaum claims that the remedial failure of a treatment's characteristic factors is the generic, objective property of a placebo. He stipulates that a treatment is placebic if this remedial failure exacerbates the target disorder. This stipulation can subsume as placebic effects that might be solely pharmacological, e.g., paradoxical reactions to certain psychiatric drugs. If that exacerbation can be explained pharmacologically, then we might question whether Grunbaum's definitional scheme captures the core identity of what we usually intend by the placebo concept. I propose that this core identity is best captured by a symbolic meaning hypothesis in which psychological factors exert the determinative influence.
Duff Waring
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Theoretical medicine and bioethics     Volume:  24     ISSN:  1386-7415     ISO Abbreviation:  Theor Med Bioeth     Publication Date:  2003  
Date Detail:
Created Date:  2003-05-08     Completed Date:  2003-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9805378     Medline TA:  Theor Med Bioeth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5-17     Citation Subset:  E; IM    
Biomedical Ethics Unit, Faculty of Medicine, McGill University, Montreal, Quebec.
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MeSH Terms
Clinical Trials as Topic / methods*
Drug Evaluation / methods*
Placebo Effect*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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