Document Detail

Paradoxical discrepancy between the serum level and the placental intensity of PP5/TFPI-2 in preeclampsia and/or intrauterine growth restriction: possible interaction and correlation with glypican-3 hold the key.
MedLine Citation:
PMID:  16580726     Owner:  NLM     Status:  MEDLINE    
There have been controversies whether maternal serum placental protein 5 (PP5)/tissue factor pathway inhibitor (TFPI)-2 is increased in the patients with preeclampsia and/or intrauterine growth restriction (IUGR). Here, we have estimated the serum PP5/TFPI-2 in these patients by a sandwich enzyme-linked immunosorbent assay with a newly developed monoclonal antibody, coupled with placental immunohistochemical studies of their placentae with semiquantitative scoring. Serum PP5/TFPI-2 level was significantly elevated only in the patients with preeclampsia alone (p=0.033), while PP5/TFPI-2 was detected significantly less intensely in the placentae of the same patients (p=0.035) in immunohistochemistry, as compared to Controls. A proteoglycan present on the placental villous surface, glypican-3, showed the same pattern of staining as PP5/TFPI-2, and there was a positive correlation (C.I.=0.506, p=0.004) between the immunohistochemical scores for these. Further experiments using HepG2 cells transfected with PP5/TFPI-2 suggested that glypican-3 could anchor PP5/TFPI-2 on the placental villi. A possibility that a decrease in glypican-3 in the placenta increases the outflow of PP5/TFPI-2, which in turn increases its serum level, was proposed. Preeclampsia and IUGR, often regarded to have the same pathological basis in common, showed distinct distributions of PP5/TFPI-2, which could be a clue to elucidate the pathogenesis of preeclampsia and IUGR.
M Ogawa; S Yanoma; Y Nagashima; N Okamoto; H Ishikawa; A Haruki; E Miyagi; T Takahashi; F Hirahara; Y Miyagi
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Publication Detail:
Type:  Journal Article     Date:  2006-03-31
Journal Detail:
Title:  Placenta     Volume:  28     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2007 Feb-Mar
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  224-32     Citation Subset:  IM    
Department of Obstetrics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
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MeSH Terms
Fetal Growth Retardation / blood,  metabolism*
Glycoproteins / blood,  metabolism*
Glypicans / metabolism*
Infant, Newborn
Placenta / metabolism*
Pre-Eclampsia / blood,  metabolism*
Syndecan-1 / metabolism
Reg. No./Substance:
0/Glycoproteins; 0/Glypicans; 0/Syndecan-1; 0/tissue-factor-pathway inhibitor 2

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