| Paradoxical aspects of rapamycin immunobiology in transplantation. | |
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MedLine Citation:
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PMID: 21446969 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Rapamycin has long been considered an immunosuppressive agent due to its antiproliferative effects on immune cells, and is currently used as a component of antirejection regimens in transplantation. Despite the large number of mechanistic and clinical studies investigating the impact of rapamycin on cell-mediated immunity, several paradoxes concerning rapamycin immunobiology remain. In particular, emerging evidence suggests that under certain circumstances rapamycin can exert immunostimulatory effects, boosting T cell responses in the face of pathogen infections and vaccines. Here, we review recent findings concerning the contradictory outcomes of rapamycin induced mTOR inhibition on CD4(+) and CD8(+) T cell responses in transplantation and protective immunity. These studies suggest that the conditions under which T cells are stimulated can profoundly modify the impact of rapamycin on antigen-specific T cell responses. Thus, further investigation into the cellular and molecular pathways underlying the dichotomous effects of rapamycin in transplantation is required to harness the full potential of this immunomodulatory agent to promote graft survival and maximize protective immunity. |
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Authors:
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I R Ferrer; K Araki; M L Ford |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: 11 ISSN: 1600-6143 ISO Abbreviation: Am. J. Transplant. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 654-9 Citation Subset: IM |
Copyright Information:
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©2011 The Authors Journal compilation©2011 The American Society of Transplantation and the American Society of Transplant Surgeons. |
Affiliation:
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Emory Transplant Center and Department of Surgery Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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