| Paradoxical Reaction of Raynaud Phenomenon Following theRepeated Administration of Iloprost in a Patient with DiffuseCutaneous Systemic Sclerosis (October). | |
| | |
MedLine Citation:
|
PMID: 23032649 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE:To report a paradoxical reaction of Raynaud phenomenon following the repeated administration of iloprost in a patient with diffuse cutaneous systemic sclerosis with vascular involvement.CASE SUMMARY:In January 2006, a 40-year-old male was diagnosed with diffuse cutaneous systemic sclerosis with pulmonary, esophageal, cutaneous, and vascular involvement (Raynaud phenomenon, with digital ulcers on his hands). In December 2008, treatment with iloprost was started due to worsening disease. Nine cycles of iloprost were administered at a rate of 0.5-1 ng/kg/min (6 hours per day, for 5 days every 6-8 weeks); the patient tolerated this treatment well. However, on the fourth day of cycles 10 and 11, the patient developed paradoxical Raynaud phenomenon in the hand with perfusion when the infusion was increased to 1 ng/kg/min, requiring treatment to be stopped. Treatment was continued during cycles 12 and 13 at 0.5 ng/kg/min; the patient tolerated the treatment well, although paradoxical Raynaud phenomenon occurred when the rate of infusion was increased.DISCUSSION:Raynaud phenomenon is extremely common in patients with scleroderma, and often is severe. Iloprost has vasodilating, antiplatelet, cytoprotective, and immunomodulating properties, and has been found to be an efficacious alternative to nifedipine for the treatment of Raynaud phenomenon in patients with scleroderma. The Naranjo probability scale indicated that iloprost was the probable cause of the paradoxical Raynaud phenomenon in this patient.CONCLUSIONS:This case demonstrates a probable relationship between the rate of infusion of iloprost and the paradoxical reaction of Raynaud phenomenon. |
| | |
Authors:
|
Rebeca Iglesias Barreira; Belén Bardán García; Mónica Granero López; Iria Rodríguez Legazpi; Hortensia Álvarez Díaz; Isaura Rodríguez Penín |
Related Documents
:
|
23659379 - The cross-talk between spinal cord stimulators and the confirm™ cardiac monitor. 23196819 - Identification of clinical predictive factors of oxaliplatin-induced chronic peripheral... 23573589 - Early onset facioscapulohumeral muscular dystrophy. 23163519 - Association between heart rate variability and systemic endothelin-1 concentration in n... 23337429 - Trends in clinical profile and medical treatments of atrial fibrillation patients over ... 736659 - A sequential, prospective analysis of immunologic abnormalities and infection following... 22739179 - Analysis on 71 patients with polycythemia vera. 10986209 - Perceptual responses in patients with inflammatory and functional bowel disease. 7223599 - Effects of verapamil on supraventricular tachycardia in patients with overt and conceal... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-2 |
Journal Detail:
|
Title: The Annals of pharmacotherapy Volume: - ISSN: 1542-6270 ISO Abbreviation: Ann Pharmacother Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
< Ferrol Health District, Ferrol, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Examination of the Relationship Between Antimicrobials andThrombocytosis (October).
Next Document: Proton Pump Inhibitor Use and Association with SpontaneousBacterial Peritonitis in Patients with Cir...