Document Detail

Paradoxical Heart Failure Precipitated by Profound Dehydration: Intraventricular Dynamic Obstruction and Significant Mitral Regurgitation in a Volume-Depleted Heart.
Jump to Full Text
MedLine Citation:
PMID:  23709446     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Occurrence of dynamic left ventricular outflow tract (LVOT) obstruction is not infrequent in critically ill patients, and it is associated with potential danger. Here, we report a case of transient heart failure with hemodynamic deterioration paradoxically induced by extreme dehydration. This article describes clinical features of the patient and echocardiographic findings of dynamic LVOT obstruction and significant mitral regurgitation caused by systolic anterior motion of the mitral valve in a volume-depleted heart.
Authors:
Dongmin Kim; Jeong-Beom Mun; Eun Young Kim; Jeonggeun Moon
Related Documents :
15951316 - Prognostic value of serum concentration of heart-type fatty acid-binding protein relati...
15010746 - Acute myocardial infarction in alberta: temporal changes in outcomes, 1994 to 1999.
17063946 - Aldosterone blockade in post-acute myocardial infarction heart failure.
18079566 - Incidence of first acute myocardial infarction in the netherlands.
19359626 - Comparison of 10 perfusion mri parameters in 97 sub-6-hour stroke patients using voxel-...
3776846 - Effect of thrombolysis (streptokinase) on left ventricular function during acute myocar...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Yonsei medical journal     Volume:  54     ISSN:  1976-2437     ISO Abbreviation:  Yonsei Med. J.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0414003     Medline TA:  Yonsei Med J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1058-1061     Citation Subset:  -    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Gachon University of Medicine and Science, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 405-760, Korea. jeff76@gilhospital.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yonsei Med J
Journal ID (iso-abbrev): Yonsei Med. J
Journal ID (publisher-id): YMJ
ISSN: 0513-5796
ISSN: 1976-2437
Publisher: Yonsei University College of Medicine
Article Information
Download PDF
© Copyright: Yonsei University College of Medicine 2013
open-access:
Received Day: 24 Month: 4 Year: 2012
Revision Received Day: 13 Month: 8 Year: 2012
Accepted Day: 14 Month: 9 Year: 2012
Print publication date: Day: 01 Month: 7 Year: 2013
Electronic publication date: Day: 14 Month: 5 Year: 2013
Volume: 54 Issue: 4
First Page: 1058 Last Page: 1061
PubMed Id: 23709446
ID: 3663219
DOI: 10.3349/ymj.2013.54.4.1058

Paradoxical Heart Failure Precipitated by Profound Dehydration: Intraventricular Dynamic Obstruction and Significant Mitral Regurgitation in a Volume-Depleted Heart
Dongmin Kim1
Jeong-Beom Mun2
Eun Young Kim3
Jeonggeun Moon4
1Cardiology Division, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
2Presbyterian Medical Center, Jeonju, Korea.
3Department of Radiology, Gachon University of Medicine and Science, Incheon, Korea.
4Division of Cardiology, Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
Correspondence: Corresponding author: Dr. Jeonggeun Moon, Division of Cardiology, Department of Internal Medicine, Gachon University of Medicine and Science, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 405-760, Korea. Tel: 82-32-460-8305, Fax: 82-32-469-1906, jeff76@gilhospital.com

INTRODUCTION

Dynamic left ventricular outflow tract (LVOT) obstruction is typically observed in patients with hypertrophic cardiomyopathy as a consequence of systolic anterior motion (SAM) of the mitral valve (MV) leaflet and hypertrophied septum. In addition, dynamic intraventricular obstruction with/without mitral regurgitation (MR) has been reported in patients with specific conditions, including acute coronary syndrome,1 after valve surgery,2 stress-induced cardiomyopathy,3 and even in a setting of structurally normal heart with precipitating factors.4,5 Here, we report a case of extreme dehydration in a patient suffering from transient heart failure and hemodynamic deterioration due to dynamic LVOT obstruction and significant MR induced by SAM of the MV, which occurred in a volume-depleted heart.


CASE REPORT

A 59 year-old Asian female presented with dyspnea (New York Heart Association class III/IV) which had developed and became aggravated over past several days. The patient had medical histories of old cerebrovascular accident and epilepsy. She hemodyhad not taken any food or water for a week due to long-standing anorexia and vomiting associated with her brain disease. Vital signs were notable with regard to hypotension (80/50 mm Hg) and tachycardia (heart rate: 110/min). On physical examination, she appeared tachypneic (respiratory rate: 20/min) with decreased skin turgor and a dry tongue. On auscultation, a systolic murmur (grade IV/VI) was audible at the left lower sternal border. Of note, chest radiography revealed newly developed pulmonary congestion (Fig. 1), which was unexpected. A 12-lead electrocardiography examination showed sinus tachycardia and nonspecific changes of ST-segment and T-wave. Laboratory findings revealed high plasma osmolality (388 mOsm/kg), hypernatremia (plasma sodium concentration: 167 mEq/L), uremia (blood urea nitrogen was 79.5 mg/dL) and increased plasma creatinine level (2.4 mg/dL), which were all suggestive of systemic dehydration. Hemoglobin was decreased to 8.4 g/dL. Serum protein was 7.6 g/dL and albumin was 3.2 g/dL.

The patient underwent transthoracic echocardiography for further evaluation of systolic murmur and cardiac pathology potentially associated with hemodynamic instability and pulmonary edema. Results showed SAM and incomplete coaptation of the MV (Fig. 2). And the left ventricular (LV) cavity was small (LV end-diastolic dimension: 39 mm) with notable hyperdynamic LV contraction (LV ejection fraction: 78%), suggesting intracardiac volume depletion. Although severe asymmetrical or concentric LV wall hypertrophy was not evident, relative wall thickness was 0.46 and LV mass index was 94 gm/m2, and those values corresponded to concentric remodeling of the LV (Fig. 2). Color Doppler evaluation showed significant eccentric MR caused by SAM of the MV (vena contracta width: 0.8 cm, effective regurgitant orifice: 0.6 cm2 and regurgitant volume: 60 mL, calculated with proximal isovelocity surface area method); however, MV itself was otherwise normal (Fig. 2). Continuous Doppler study of the LVOT showed a late-peaking profile of the flow with a maximal pressure gradient of 119 mm Hg estimated by systolic blood flow velocity, and it was suggestive of significant dynamic LVOT obstruction (Fig. 2). Meanwhile, early diastolic mitral inflow velocity (E) was 0.9 m/s and early diastolic mitral annulus velocity (E') at the septal corner was 0.04 m/s (E/E' ratio: 23). Inferior vena cava diameter was 1.1 cm and also showed good collapsibility (respiratory variability was above 50%).

Despite pulmonary edema on the chest radiography, we decided to restore the patient's systemic volume, because the cause of pulmonary congestion was not due to absolute systemic volume overload, but due to intracardiac volume maldistribution resulting from SAM of the MV in the volume depleted heart. After receiving fluid therapy with crystalloid and other nutritional support for five days, the patient's condition stabilized and laboratory findings gradually returned to normal. Echocardiographic evaluation performed after treatment revealed complete resolution of SAM of the MV and disappearance of the preexisting dynamic LVOT obstruction and significant MR (Fig. 3). At the same time, E/E' ratio was decreased to 13, indicating reduced left atrial (LA) pressure compared to previous study. On hospital day 38, the patient was discharged in good condition.


DISCUSSION

Our patient suffered transient heart failure with hemodynamic deterioration due to the unexpected cause of profound dehydration; therefore, the present case is clinically meaningful and provides helpful insights into intracardiac hemodynamics in a volume-depleted heart. Newly developed pulmonary congestion was suspected on the chest radiography, however, it was counterintuitive, since she was extremely dehydrated. Dehydration itself is hardly regarded as a postulated cause of cardiac failure and pulmonary edema. Interestingly, however, acute heart failure with hemodynamic impairment was paradoxically precipitated by profound dehydration in this case. In addition, careless administration of diuretics, vasodilators or catecholamine, which is mainstay of treatment of heart failure, might have been a critical mistake in this intriguing clinical setting.

Those unusual manifestations were successfully explained by echocardiography, which revealed SAM of the MV, resultant dynamic LVOT obstruction and significant MR. Dynamic LVOT obstruction with/without MR, which is often recognized in critically ill patients with or even without structural heart disease, is potentially fatal.6 The majority of patients with dynamic LVOT obstruction without organic heart disease have a history of hypertension with some degree of concentric hypertrophy and precipitating factors, such as catecholamine administration, sepsis, blood loss or dehydration, etc.4-6 In the current case, profound dehydration and anemia precipitated intraventricular obstruction and significant MR, thereby inducing an acute drop in cardiac output along with hemodynamic impairment. The patient's medical history of old cerebrovascular accident might have affected thirst and satiety mechanism of the patient7 providing a plausible explanation for the patient's extreme dehydration.

Classically, the cardinal features of cardiogenic shock include increased pulmonary capillary wedge pressure and decreased cardiac output, whereas the characteristics of hypovolemic shock include low pulmonary capillary wedge pressure and reduced cardiac output.8 Due to differences in management strategies, distinguishing between cardiogenic and hypovolemic shock is critical. In the present case, pulmonary congestion was notable and it was considered to be a consequence of elevation of pulmonary capillary pressure due to increased LA pressure which resulted from intracardiac dynamic obstruction and significant MR. Therefore, the cause of the patient's hypotension was cardiogenic rather than hypovolemic, and early recognition of the unexpected hemodynamic feature was essential for legitimate treatment. In this point of view, echocardiography was an invaluable tool in our case to define the etiology of the shock and to determine the proper management plan.


Notes

The authors have no financial conflicts of interest.

ACKNOWLEDGEMENTS

This work is supported by Boryung Pharmaceutical Company, Republic of Korea.


References
1. Haley JH,Sinak LJ,Tajik AJ,Ommen SR,Oh JK. Dynamic left ventricular outflow tract obstruction in acute coronary syndromes: an important cause of new systolic murmur and cardiogenic shockMayo Clin ProcYear: 19997490190610488794
2. Aurigemma G,Battista S,Orsinelli D,Sweeney A,Pape L,Cuénoud H. Abnormal left ventricular intracavitary flow acceleration in patients undergoing aortic valve replacement for aortic stenosis. A marker for high postoperative morbidity and mortalityCirculationYear: 1992869269361516206
3. Villareal RP,Achari A,Wilansky S,Wilson JM. Anteroapical stunning and left ventricular outflow tract obstructionMayo Clin ProcYear: 200176798311155418
4. Mingo S,Benedicto A,Jimenez MC,Pérez MA,Montero M. Dynamic left ventricular outflow tract obstruction secondary to catecholamine excess in a normal ventricleInt J CardiolYear: 200611239339616290226
5. Yang JH,Park SW,Yang JH,Cho SW,Kim HS,Choi KA,et al. Dynamic left ventricular outflow tract obstruction without basal septal hypertrophy, caused by catecholamine therapy and volume depletionKorean J Intern MedYear: 20082310610918646515
6. Chockalingam A,Dorairajan S,Bhalla M,Dellsperger KC. Unexplained hypotension: the spectrum of dynamic left ventricular outflow tract obstruction in critical care settingsCrit Care MedYear: 20093772973419114882
7. Verbalis JG. Disorders of body water homeostasisBest Pract Res Clin Endocrinol MetabYear: 20031747150314687585
8. Topalian S,Ginsberg F,Parrillo JE. Cardiogenic shockCrit Care MedYear: 2008361 SupplS66S7418158480

Article Categories:
  • Case Report
    • Cardiac & Cardiovascular Systems

Keywords: Dynamic obstruction, mitral regurgitation, shock, dehydration, echocardiography.

Previous Document:  Novel Mutations in the UNC13D Gene Carried by a Chinese Neonate with Hemophagocytic Lymphohistiocyto...
Next Document:  Hybrid Method of Transurethral Resection of Ejaculatory Ducts Using Holmium:Yttriumaluminium Garnet ...