| Paradigm shift in the role of uric Acid in acute kidney injury. | |
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MedLine Citation:
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PMID: 22000653 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It has been known for decades that uric acid causes acute kidney injury by intratubular crystal precipitation and obstructing the renal tubules. Uric acid crystals stimulate inflammation and elicit immune responses in many disease conditions, including gouty arthritis. More recently, soluble uric acid has been reported to stimulate proliferation of vascular smooth muscle cells, inhibit endothelial function, cause renal vasoconstriction, impair renal blood flow autoregulation, and induce inflammatory response via crystal-independent mechanisms. This article examines the changing role for uric acid in acute kidney injury. |
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Authors:
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Michiko Shimada; Bhagwan Dass; A Ahsan Ejaz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in nephrology Volume: 31 ISSN: 1558-4488 ISO Abbreviation: Semin. Nephrol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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