| Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome. | |
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MedLine Citation:
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PMID: 12495719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adipocytes anatomically associated with lymph nodes and omental milky spots have site-specific properties that equip them to interact locally with lymphoid cells. Paracine provisioning of peripheral immune responses improves their efficiency and emancipates activated lymphocytes from competition with other tissues for blood-borne nutrients. Prolonged disruption to such paracine interactions might contribute to the HIV-associated adipose redistribution syndrome, causing selective hypertrophy of the mesentery, omentum and other lymphoid tissue-containing adipose depots, while nodeless depots atrophy. |
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Authors:
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Caroline M Pond |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in immunology Volume: 24 ISSN: 1471-4906 ISO Abbreviation: Trends Immunol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-23 Completed Date: 2004-01-09 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 13-8 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK. c.m.pond@open.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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cytology,
drug effects,
metabolism*,
pathology* Animals HIV-Associated Lipodystrophy Syndrome / metabolism*, pathology*, virology Humans Lymphoid Tissue / metabolism*, virology Organ Specificity Paracrine Communication* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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