Document Detail

Paracetamol poisoning in pregnancy: an analysis of the outcomes of cases referred to the Teratology Information Service of the National Poisons Information Service.
MedLine Citation:
PMID:  2198067     Owner:  NLM     Status:  MEDLINE    
A study was carried out to investigate the outcome of pregnancy in 115 women who had been exposed to paracetamol overdose. Follow up was obtained in 48 cases. Exposure occurred in all trimesters, and the most striking feature of this series is that the majority of the pregnancy outcomes were normal. None of the mothers died. There were 39 live born infants with no malformation, 14 of whom had been exposed in the first trimester. Four babies, exposed in the third trimester had neonatal problems, but these seem unrelated to paracetamol. There were two live born infants with gross malformations (spina bifida occulta; and cleft lip and palate). However, as the overdoses occurred at weeks 26 and 28 respectively, long after the structural development of these organs, the malformations could not have been caused by the paracetamol. There were two spontaneous abortions, both in the first trimester, which occurred two weeks after the overdose which may be related to the paracetamol. The overall conclusion is that paracetamol overdose per se is not necessarily an indication for termination of pregnancy.
P R McElhatton; F M Sullivan; G N Volans; R Fitzpatrick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  9     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-09-04     Completed Date:  1990-09-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Department of Pharmacology and Toxicology, UMDS, London, UK.
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MeSH Terms
Abnormalities, Drug-Induced
Acetaminophen / poisoning*
Follow-Up Studies
Infant, Newborn
Information Services
Pregnancy Complications / chemically induced*
Prenatal Exposure Delayed Effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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