Document Detail

Paraben allergy.
MedLine Citation:
PMID:  576658     Owner:  NLM     Status:  MEDLINE    
A hydrocortisone preparation containing methylparaben and propylparaben provoked bronchospasm and pruritus when given intravenously to an asthmatic patient, whereas another hydrocortisone preparation without paraben preservative did not. Direct and passive transfer (Prausnitz-Küstner) skin tests for immediate hypersensitivity to parabens were positive. Parabens, frequently employed as bacteriostatic agents, are capable of producing immunologically mediated, immmediate systemic hypersensitivity reactions.
J E Nagel; J T Fuscaldo; P Fireman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  237     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1594-5     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / drug therapy*
Bronchial Spasm / chemically induced*
Drug Hypersensitivity / etiology*
Hypersensitivity, Immediate / chemically induced*
Parabens / adverse effects*,  immunology,  therapeutic use
Pruritus / chemically induced*
Skin Tests / methods
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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