Document Detail

Para-dichlorobenzene toxicity - a review of potential neurotoxic manifestations.
MedLine Citation:
PMID:  24790648     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Para-dichlorobenzene (PDCB) is an active ingredient of mothballs, deodorizers and fumigants. Due to the easy availability of this chemical, there is a considerable risk for accidental or intentional toxic exposure. Recently, multiple cases of PDCB toxicity due to mothball ingestion were reported. PDCB toxicity can affect multiple organ systems including liver, kidneys, skin, lung and the central nervous system (CNS). CNS toxicity often results in leukoencephalopathy and heterogeneous neurological manifestations.
OBJECTIVES: The objective of this study was to illustrate the clinical presentation, imaging findings, diagnosis and management of PDCB toxicity.
METHODS: We carried out a literature review of the pharmacological and toxicological properties of PDCB.
CONCLUSIONS: PDCB and other aromatic hydrocarbons are capable of CNS tissue damage and in promoting functional neurological decline. While very little is currently known about prevalence of PDCB addiction, it cannot be ruled out that its illicit use among young people is under-recognized. The number of cases of PDCB toxicity might also rise due to the increasing industrial and domestic use of this chemical.
Divyanshu Dubey; Vibhash D Sharma; Steven E Pass; Anshudha Sawhney; Olaf Stüve
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Therapeutic advances in neurological disorders     Volume:  7     ISSN:  1756-2856     ISO Abbreviation:  Ther Adv Neurol Disord     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-05-05     Completed Date:  2014-06-24     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101480242     Medline TA:  Ther Adv Neurol Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-87     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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