Document Detail

Papillomavirus prophylactic vaccines: established successes, new approaches.
MedLine Citation:
PMID:  19906917     Owner:  NLM     Status:  MEDLINE    
Vaccines against the human papillomaviruses (HPVs) most frequently associated with cancer of the cervix are now available. These prophylactic vaccines, based on virus-like particles (VLPs), are extremely effective, providing protection from infection in almost 100% of cases. However, the vaccines present some limitations: they are effective primarily against the HPV type present in the vaccine, are expensive to produce, and need a cold chain. Vaccines based on the minor capsid protein L2 have been very successful in animal models and have been shown to provide a good level of protection against different papillomavirus types. The potential of L2-based vaccines to protect against many types of HPVs is discussed.
M Saveria Campo; Richard B S Roden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-11
Journal Detail:
Title:  Journal of virology     Volume:  84     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-02-18     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1214-20     Citation Subset:  IM    
Division of Pathological Sciences, Institute of Comparative Medicine, Garscube Campus, University of Glasgow, Glasgow G61 1QH, United Kingdom.
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MeSH Terms
Alphapapillomavirus / chemistry,  genetics,  physiology,  ultrastructure
Microscopy, Electron
Papillomavirus Infections / prevention & control*
Papillomavirus Vaccines / administration & dosage*
Grant Support
P50 CA098252/CA/NCI NIH HHS; R01 CA118790/CA/NCI NIH HHS; R01 CA133749/CA/NCI NIH HHS; //Cancer Research UK
Reg. No./Substance:
0/Papillomavirus Vaccines; 0/human papillomavirus vaccine L1, type 6,11,16,18

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