| Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate. | |
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MedLine Citation:
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PMID: 21080253 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Elevated levels of D: -2-hydroxyglutarate (D: -2-HG) occur in gliomas and myeloid leukemias associated with mutations of IDH1 and IDH2. L: -2-Hydroxyglutaric aciduria, an inherited metabolic disorder, predisposes to brain tumors. Therefore, we asked whether sporadic cancers, without IDH1 or IDH2 hot-spot mutations, show elevated 2-hydroxyglutarate levels. We retrieved 15 pairs of frozen papillary thyroid carcinoma (PTC) and adjacent non-neoplastic thyroid, and 14 pairs of hyperplastic nodule (HN) and adjacent non-hyperplastic thyroid. In all lesions, exon 4 sequencing confirmed the absence of known mutations of IDH1 and IDH2. We measured 2-hydroxyglutarate by liquid chromatography-tandem mass spectrometry. Compared to normal thyroid, PTCs had significantly higher D: -2-HG and L: -2-hydroxyglutarate (L: -2-HG) levels, and compared to HNs, PTCs had significantly higher D: -2-HG levels. D: -2-HG/L: -2-HG levels were not significantly different between HNs and normal thyroid. Further studies should clarify if elevated 2-hydroxyglutarate in PTC may be useful as cancer biomarker and evaluate the role of 2-hydroxyglutarate in cancer biology. |
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Authors:
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Dinesh Rakheja; Richard L Boriack; Midori Mitui; Shama Khokhar; Shelby A Holt; Payal Kapur |
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Publication Detail:
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Type: Journal Article Date: 2010-11-16 |
Journal Detail:
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Title: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Volume: 32 ISSN: 1423-0380 ISO Abbreviation: Tumour Biol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8409922 Medline TA: Tumour Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 325-33 Citation Subset: IM |
Affiliation:
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Department of Pathology, Children's Medical Center, Dallas, TX, USA, dinesh.rakheja@utsouthwestern.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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