Document Detail

Papillary carcinoma of the thyroid with exuberant nodular fasciitis-like stroma.
MedLine Citation:
PMID:  9368667     Owner:  NLM     Status:  MEDLINE    
We describe a rare case of papillary carcinoma with extensive proliferation of stromal cells. The stromal cells were immunocytochemically positive for vimentin, alpha-smooth muscle actin and desmin, but negative for cytokeratin, epithelial membrane antigen, S-100, thyroglobulin and CD34. These results and the ultrastructure of the stromal cells, which exhibited the characteristics of both fibroblasts and smooth muscle cells, indicated an origin from myofibroblasts. We conclude that myofibroblastic proliferation may contribute to the stromal response in the slow growth of the papillary carcinoma.
K Terayama; S Toda; N Yonemitsu; N Koike; H Sugihara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  431     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-10     Completed Date:  1997-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Department of Pathology, Saga Medical School, Japan.
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MeSH Terms
Carcinoma, Papillary / metabolism,  pathology*
Fasciitis / pathology*
Fibroblasts / pathology
Middle Aged
Muscle, Smooth / pathology
Thyroid Neoplasms / metabolism,  pathology*

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