Document Detail


Paper 5: Surveillance of multiple congenital anomalies: Implementation of a computer algorithm in European registers for classification of cases.
MedLine Citation:
PMID:  21384529     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Surveillance of multiple congenital anomalies is considered to be more sensitive for the detection of new teratogens than surveillance of all or isolated congenital anomalies. Current literature proposes the manual review of all cases for classification into isolated or multiple congenital anomalies. METHODS: Multiple anomalies were defined as two or more major congenital anomalies, excluding sequences and syndromes. A computer algorithm for classification of major congenital anomaly cases in the EUROCAT database according to International Classification of Diseases (ICD)v10 codes was programmed, further developed, and implemented for 1 year's data (2004) from 25 registries. The group of cases classified with potential multiple congenital anomalies were manually reviewed by three geneticists to reach a final agreement of classification as "multiple congenital anomaly" cases. RESULTS: A total of 17,733 cases with major congenital anomalies were reported giving an overall prevalence of major congenital anomalies at 2.17%. The computer algorithm classified 10.5% of all cases as "potentially multiple congenital anomalies". After manual review of these cases, 7% were agreed to have true multiple congenital anomalies. Furthermore, the algorithm classified 15% of all cases as having chromosomal anomalies, 2% as monogenic syndromes, and 76% as isolated congenital anomalies. The proportion of multiple anomalies varies by congenital anomaly subgroup with up to 35% of cases with bilateral renal agenesis. CONCLUSIONS: The implementation of the EUROCAT computer algorithm is a feasible, efficient, and transparent way to improve classification of congenital anomalies for surveillance and research. Birth Defects Research (Part A), 2011. © 2011 Wiley-Liss, Inc.
Authors:
Ester Garne; Helen Dolk; Maria Loane; Diana Wellesley; Ingeborg Barisic; Elisa Calzolari; James Densem;
Related Documents :
7246489 - The puppet-like syndrome of angelman.
1592029 - Compulsive somatosensory self-stimulation inducing epileptic seizures.
11718749 - A cadasil case with normal skin biopsy and without mutations in exons 3 and 4 of the no...
3939749 - Pathologic myoclonus of the newborn: electrographic and clinical correlations.
7454649 - Temporal arteritis presenting as ataxia and dementia.
1125849 - The clinical significance of a single unilateral temporal pterygium.
19172509 - Congenital alacrima in a patient with blepharophimosis syndrome.
10580189 - Ending polio immunisation: stars and gutters.
23864979 - Pelvic mass 21 years after total hip arthroplasty.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-7
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  -     ISSN:  1542-0760     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Hospital Lillebaelt, Kolding, Denmark. ester.garne@slb.regionsyddanmark.dk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lack of correlation between portal vein flow and pressure: Towards a shared interpretation of hemody...
Next Document:  Paper 3 EUROCAT data quality indicators for population-based registries of congenital anomalies†