Document Detail

Papaverine testing of impotent patients following nerve-sparing radical prostatectomy.
MedLine Citation:
PMID:  3352039     Owner:  NLM     Status:  MEDLINE    
To investigate the etiology of impotence following nerve-sparing radical retropubic prostatectomy we performed papaverine testing on 23 patients who did not regain erections sufficient for vaginal penetration. Intervals from surgery to testing ranged from 3 to 30 months, with an average of 9 months. All patients achieved some degree of tumescence. In response to intracavernous papaverine injection only 1 patient (5 per cent) obtained an erection equivalent to the preoperative state. Of 18 patients who were fully potent preoperatively 8 (44 per cent) achieved an erection less than normal but judged to be sufficient for intercourse by the examining physician. Twelve patients, including 2 who were not fully potent preoperatively, had erections of poor quality insufficient for vaginal penetration. The results suggest that in most of these patients postoperative erectile dysfunction is predominantly vasculogenic in origin. Thus, factors other than injury to the neurovascular bundles may be responsible for postoperative impotence.
R R Bahnson; W J Catalona
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of urology     Volume:  139     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-04-29     Completed Date:  1988-04-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-4     Citation Subset:  AIM; IM    
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri.
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MeSH Terms
Erectile Dysfunction / etiology*
Papaverine / diagnostic use*
Penile Erection / drug effects*
Postoperative Complications / etiology
Prostatectomy / adverse effects*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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