| Pantoprazole and perinuclear antineutrophil cytoplasmic antibody-associated vasculitis. | |
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MedLine Citation:
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PMID: 16482642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic vasculitis may, at times, be drug-induced and associated with antineutrophil cytoplasmic antibodies (ANCA). However, pantoprazole, a commonly used and well-tolerated proton pump inhibitor, has not previously been reported to cause ANCA-associated syndromes. We describe a patient who developed interstitial nephritis, cutaneous vasculitis, a perinuclear ANCA staining pattern (pANCA) on immunofluorescence, and anti-myeloperoxidase antibodies (MPO-ANCA) in association with pantoprazole. We review various immune-mediated syndromes reported in association with proton pump inhibitors, including one report of omeprazole associated with interstitial nephritis and the development of ANCA. |
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Authors:
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Dana Jacobs-Kosmin; Chris T Derk; Nora Sandorfi |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-02-15 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 33 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-02 Completed Date: 2006-07-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 629-32 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Acute Disease Aged Anti-Ulcer Agents / adverse effects* Antibodies, Antineutrophil Cytoplasmic / blood* Benzimidazoles / adverse effects* Cell Nucleus / immunology, pathology* Chronic Disease Exanthema / chemically induced, immunology, therapy Female Humans Methylprednisolone / therapeutic use Nephritis, Interstitial / chemically induced, immunology, therapy Omeprazole / adverse effects, analogs & derivatives* Peroxidase / immunology Renal Dialysis Sulfoxides / adverse effects* Treatment Outcome Vasculitis, Leukocytoclastic, Cutaneous / chemically induced*, immunology, therapy |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Antibodies, Antineutrophil Cytoplasmic; 0/Benzimidazoles; 0/Sulfoxides; 102625-70-7/pantoprazole; 73590-58-6/Omeprazole; 83-43-2/Methylprednisolone; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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