| Panhypopituitarism secondary to a macroprolactinoma presenting with pancytopenia. A case report and literature review. | |
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MedLine Citation:
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PMID: 21247847 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: We present a case of pancytopenia associated with hypopituitarism secondary to a macroprolactinoma.Methods: We present the clinical features on presentation and results of laboratory investigation. MRI findings are illustrated. The response to hormone replacement therapy is shown.Results: A 46 year old man was referred with pancytopenia and secondary hypothyroidism. Laboratory investigation revealed hypopituitarism and a raised prolactin. MRI demonstrated a macroprolactinoma. Haematological investigation revealed no other cause for the pancytopenia. Hormone replacement was commenced with hydrocortisone, thyroxine and testosterone. Carbergoline was used to induce regression of the prolactinoma. A rapid improvement was seen in the cytopenias with normalisation of the blood count after 8 months of treatment. This has been sustained over 29 months follow up.Conclusion: Pancytopenia associated with hypopituitarism has been reported in the literature as a rare occurrence limited to isolated case reports, predominantly associated with Sheehan's Syndrome. To our knowledge, this is the first reported case of pancytopenia associated with a macroprolactinoma. This is significant as prolactin alone has been reported to support haematopoiesis in animal studies. |
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Authors:
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George I Holmes; Pat Shepherd; James D Walker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-17 |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
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Languages: ENG Pagination: 1-13 Citation Subset: - |
Affiliation:
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Department of Haematology, St John's Hospital, Livingston, EH45 6PP. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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